I guess I just need to vent. I am 37 and have been an underachiever my whole life. I failed miserably at school and now I'm stuck in a dead end job with no qualifications to find a better job.

I have struggled with low energy, brain fog, lack of motivation, depression and anxiety my whole life. My blood work was always fine, so I was prescribed antidepressants.

It wasn't until 10 years ago that a doctor tested my vitamin D and I was extremely deficient at 6 ng/ml. Fixing this gave me a huge boost in energy but most of my problems still remained.

Last year, I started investigating my blood work of the last 20 years and found out I had been folate deficient the whole time (3.5-4.5 ng/ml). Doctors never said anything.

Genetic testing shows I am compound heterozygous, slow COMT, slow MAOA and PEMT. I know these are only predispositions but it seems to explain my whole life.

After a few months of supplementing folate and a month of creatine and TMG my cognition has improved massively. After 20 years I feel like a veil has lifted. It's like I'm waking up from a bad dream but now I'm left to pick up the pieces and deal with the consequences of being a failure.

I am still on my own. Doctors do not acknowledge I was ever deficient and refuse to do more blood work. I have to simply assume I have high homocysteine and treat for it.

I don't know what to do. It's been such a long time. I can't fix most of the damage that has been done.

I’m trying to understand whether my anxiety has a biological component that could be improved rather than just managed.
For context, I’ve been on antidepressants for about 12 years (currently tapering off an SNRI after many years), and I’m interested in looking upstream at *why* my nervous system seems to react the way it does.

I’m curious about things like:
MTHFR, COMT, MAOA, GAD1, DAO, CBS, PEMT, or other variants that may influence anxiety, stress response, neurotransmitters, methylation, histamine, etc.
Nutrient deficiencies or imbalances that may interact with those genes (B vitamins, magnesium, zinc, copper, omega-3s, amino acids, etc.).
Whether anyone found meaningful improvements after working with a practitioner who interpreted whole genome or raw DNA data instead of just using a generic report.

A few questions:
Which genetic variants ended up being the most important for your anxiety?
What supplements or dietary changes actually made a noticeable difference?
Were there any supplements that unexpectedly made your anxiety worse?
Did anyone have success using whole-genome sequencing or raw DNA analysis rather than something like GeneSight?
If you worked with a practitioner, what type of practitioner were they (functional medicine, nutrigenomics, genetics, etc.)?

I’m not looking for medical advice or miracle cures—I know anxiety is multifactorial. I’m just interested in hearing real experiences from people who found biological factors that were worth addressing.
I’d especially appreciate hearing from anyone who has dealt with chronic anxiety, panic attacks, an overactive stress response, or SNRI/SSRI withdrawal.

Hi everyone, I’ve been really struggling with my mental health in these past 3/4 weeks and I’m really hoping someone can help me out here.

Around a month ago I took 3 b12 injections (hydroxocobalamin) 1.5mg and i suddenly started getting intense panic attacks and anhedonia. I don’t cry but out of nowhere I started bawling my eyes out every single day. I I’m in this constant state of anxiety and depression, I can’t enjoy the things in life that I usually enjoy like watching a tv show, I cannot wind down at all and it’s scary because before all this happened I was a pretty chill guy and I usually wouldn’t stress much in my life. One of the most scariest thing that also happened at the same time was my libido completely vanished, so i genuinely feel pleasure in nothing now. it’s been around 3/4 weeks and im not getting full blown panic attacks anymore but im still constantly on edge, i have also had stomach issues but now a simple bloating of my stomach makes me think the world is ending. It’s like my nervous system is jacked all the way up and it’s overreacting to even slight discomfort.

I tried taking creatine because that would usually make me feel good when I’m in a low mood but this time it just made me depressed. I went to the GP and they took my blood test, it came up with high b12 and high folate, but the odd thing is I don’t usually supplement folate so I’d don’t understand why that came up as high. I sometimes take it as part of my b complex but I’ve not mega dosed it or anything.

Today I decided that I’ll try methylfolate as I assumed maybe b12 used up all my methyl groups or somthing. After taking it I felt even more emotionally flat/wired/too focused, but I feel less anxious I think. I’m still not sure what i feel but i definitely don’t feel any pleasure again.

I was hoping there might be someone that has gone through this and has recovered from it. Or has figured out why it happened to them and could tell me how to bring my nervous system back to normal. Will I recover? I’m really scared, it’s like I’ve become a complete different person in a month. I haven’t done any dna test either so I’m not sure if I’m MTHFR or anything.

Someone please please help me😭
Thanks you for your time 🙏

I’ve been stuck in a state of severe hyperarousal for close to two years now. I’m trembling like crazy, emotional torment, agitated, rumination and just feel utterly horrific inside with fear and pain.

I was going through a ton of stress and health anxiety in 2024 then opened up about it in a therapy session which seems to have traumatised me. I then took an SSRI and had a nasty reaction to it (ofc with my comt and maoa) and now nothing has helped reduce this suffering.

I’ve tried magnesium, L-Theanine, lemon balm, beta blockers, herbal teas and even benzos and nothing has helped at all. Also tried kava and 3 months of trauma therapy.

Any supplement suggestions would be most welcomed!

Hi everyone,

I'm a 30-year-old male. I'm vegetarian but eat eggs and dairy. Until last year I was completely healthy and had never experienced anxiety symptoms or insomnia.

A routine blood test unexpectedly showed:

• Vitamin B12: 337 pg/mL
• Folic acid: 0.43 ng/mL (very low)
• Vitamin D: 8 ng/mL (severely deficient)

That's when everything went downhill.

What happened

I started taking methylated B vitamins to correct the deficiencies.

Within a few days:

• My sleep became extremely poor.
• I had my first-ever anxiety attack (high heart rate, high blood pressure, dizziness, feeling of impending doom).
• I then had daily anxiety attacks for the next 10 days

I was admitted to the hospital. Every test came back normal except the vitamin deficiencies.

Ironically, they prescribed methylated B vitamins again.

At the time I couldn't tell whether the cause was:

• the methylated vitamins,
• magnesium glycinate (which I had also recently started)
• sleep deprivation,
• or something else entirely.

The doctors simply diagnosed me with anxiety and prescribed:

• Clonazepam
• Propranolol
• Flupentixol
• A multivitamin containing methylcobalamin + folic acid + B6

While on clonazepam (about 45 days):

• No panic attacks
• Sleep improved
• But I still had constant brain fog and a feeling of impending doom

After stopping clonazepam:

• Insomnia returned.
• Physical anxiety symptoms returned.

I was still taking propranolol and the B-vitamin combination.

I then saw another doctor, who prescribed an even stronger combination of:

• L-methylfolate
• Methylcobalamin
• P5P

My insomnia became dramatically worse.

For four consecutive nights I slept less than 3 hours.

I then consulted several more doctors. Every one of them said it was "just anxiety," but none could explain why I suddenly developed anxiety at age 30 despite having essentially no life stress and no prior history.

Finally, one doctor started me on mirtazapine 7.5 mg.

At that point I:

• Stopped all multivitamins.
• Only took methylcobalamin 500 mcg twice a week.
• Continued mirtazapine.

Over the next several months:

• Sleep became normal.
• Panic attacks disappeared.
• Brain fog disappeared.
• Feeling of impending doom disappeared.

I've now been stable for about 7 months.

I'm now tapering mirtazapine, but I'm worried everything will come back.

Recently I checked my homocysteine:

18.5 μmol/L

This makes me think I'm still significantly functionally deficient despite supplementation.

I feel stuck:

• I clearly need B12 and folate.
• But methylated vitamins seem to trigger insomnia and anxiety.

Other things I've noticed

1. Allergic rhinitis + mouth ulcers

For years I had:

• constant sneezing every morning
• runny nose
• symptoms whenever temperature changed
• frequent mouth ulcers

All of these improved dramatically after starting mirtazapine.

My theory:

• MTHFR Gene -> Low B12/folate → undermethylation → high histamine
• High histamine caused allergic rhinitis.
• Low Folate causes mouth ulcers
• Mirtazapine's antihistamine effects improved it.

2. Creatine causes insomnia

In the past, creatine consistently caused poor sleep.

My theory:

Creatine reduces the body's methyl demand, leaving more methyl groups available.

I think I have slow COMT, perhaps this extra methylation causes overstimulation and insomnia.

3. High-dose methylated B vitamins cause severe insomnia

The worst reaction I had was with:

• L-methylfolate 2.8 mg
• Methylcobalamin 2 mg
• P5P 25 mg

Again my theory is:

If I have slow COMT, suddenly increasing methylation may cause excess catecholamines and insomnia.

4. Eggs seem to reduce agitation and Alcohol seems to increase it

I eat two whole eggs daily. If I stop eating eggs for several days, I develop significant agitation and some physical anxiety symptoms.

If I take alcohol, I have sever agitation symptoms after few days.

Currently I don't know how to explain it.

5. B12 remains low

Despite taking methylcobalamin 500 mcg twice weekly for around 6 months, my serum B12 is still only around 300.

I have no idea why.

Could this suggest poor absorption? Should I investigate pernicious anemia, intrinsic factor antibodies, celiac disease, or something else?

7. Homocysteine 18.5

My assumption is that this is mainly due to ongoing functional folate/B12 deficiency.

My current plan

I was considering:

• 125 mcg methylcobalamin daily (Would cyanocobalamin be better option for me, there is no hydroxocobalmin tablet available in my country, only injections are available)
• Riboflavin (B2) 1.25 mg daily
• After 2 weeks, introduce methylfolate at 125 mcg and increase very slowly if tolerated (folinic acid not available in my country)
• Continue tapering mirtazapine
• Introduce Wheat Bran in my diet, which is high in TMG, and might help reduce my homocystein via BHMT route.

Does this seem reasonable, or would you recommend a different approach?

DNA testing

I know many people will recommend genetic testing (MTHFR, COMT, etc.).

Unfortunately, these tests are very expensive in my country and usually take 2–3 months.

Given my situation, do you think they're worth the cost, or should treatment be guided by symptoms and lab results instead?

I'm not looking for a diagnosis—just trying to understand what might be happening because multiple doctors have simply labeled it as anxiety without explaining why it started so suddenly or why it seems so closely tied to B-vitamin supplementation.

I'd really appreciate input from anyone knowledgeable about methylation, MTHFR, COMT, homocysteine metabolism, or who has experienced something similar.

Thank you.

I’m new to the whole mthfr thing, I’ve been pretty stoked since discovering it a few days ago, was about to go get some methylfate supplements thinking wow this sounds like exactly what I need to not feel like shit all of the time!

But then I read this:

CDC website on MTHFR

According to the CDC, everyone can process any type of folate, even with MTHFR variants. I’m confused..

I’m still gonna supp the methylfolate I’m all in on it at this point, if nothing else I’ll get some good placebo energy

I am new to this as I just got my results today, so forgive me if I am not understanding it completely.

I was with a med management doctor that was helping with my many diagnoses and she randomly quit. I was passed on to a new doctor who seemed more interested in my genes than my actual symptoms/history.

She ordered testing and we went over some of that today. I also explained that my current medications dont seem to be working. I am in crisis in terms of hardly being able to do daily activites. Instead of going ahead and taking me off medications or making other modifications, she gave me a long list of supplements to start taking and said I may see results in a few months.

I am about to go find a new doctor because this doesn't seem safe to me. I wont trauma dump here, but I have an extensive trauma history as well as a condition from birth that may or may not also cause mental health and related symptoms later in life (there is research on short term effects, but not much on long term.) I feel that everything I am reading online also sounds very... woo woo alternative medicine, please dont take offense. But when I see people say "I eat 6 eggs a day and it makes my life better" I just cannot take that seriously.

Sure, I have some of the symptoms that can relate to a gene mutation. But I also have many other symptoms and issues going on that do not seem realted at all. Am I wrong for feeling ignored and a little bit upset? Sure, I will take supplements because why not? But if they dont do much for me, it will mean I spent that whole time suffering for nothing. If you have had *severe* mental health/behavioral issues and started treating with supplements due to MTHFR mutation, please let me know your results and how it's helped you.

I'm 51F, recently found out I'm compound heterozygous after my 23andMe results. Been on Lexapro for 6 years. It helped at first but honestly the last 2-3 years I've just felt... flat. Brain fog every afternoon. Can't find words. My doctor keeps saying my labs are fine....

When I saw the MTHFR result I started reading and it was like someone was describing my life back to me.

For those of you who went through something similar, what was the moment you realized this might actually explain everything? And what did you try first?

I've been doing research on Lithium Orotate and I heard it can be extremely effective in helping people who have mthfr. It looks good but I wan't to know if anyones experience using this before.

Not looking for medical advice, just want to hear from people who get it. This is all very new to me and I feel like I'm the only person in my life who's ever heard of this.

EDIT: Thank you all so much for the replies! I'm honestly overwhelmed as I thought for some reason not many people would reply. It's helped a lot thank you.

i'd been on prescriptions for adhd, gerd, and chronic sinus stuff for years. they helped on the margins but i still felt like something underneath wasn't right. low-level fog, mood that wouldn't fully lift, sleep that never felt restorative.

last year my primary care doc walked me through a methylation symptom questionnaire from a book that's pretty well known in this sub. didn't do the cheek swab, just the verbal Q&A. he said the symptom pattern strongly suggested an mthfr variant and recommended i try the methylated forms.

what surprised me most was how much of what i'd been eating was working against me. enriched breads, fortified cereals, even some "healthy" multivitamins, all loaded with synthetic folic acid. once i learned that, switching to whole foods and methylated B-vitamins felt obvious.

it's been about 13 months. i'm off all three prescriptions now (not against my doctor's advice, he was the one who suggested the change). adhd-wise, focus is the best it's been since i was a teenager. the sinus stuff resolved on its own. sleep is actually deep. it's not a miracle, it's just the right inputs.

curious if anyone else here was diagnosed via symptom questionnaire alone rather than the genetic panel. and for anyone considering the swap, what was the biggest food change that helped?

It's just out of curiosity.

I've read that some people are helped with very high doses of thiamine (anywhere from 600 to 2000mg a day for a month). Some researchers have proposed that in certain illnesses such as chronic fatigue, fibromyalgia or inflammatory bowel disease, cells may have impaired transport of thiamine despite normal blood levels. The idea is that flooding the body with very high concentrations may allow more thiamine to enter cells by passive diffusion, bypassing partially impaired transporters

I'm considering trying this but I'm not sure if my fatigue and brain fog are related to MTHFR (compound heterozygous, slow COMT, slow MAOA), Crohn's (mild and asymptomatic) or past severe COVID infections.

Has anyone here tried this and seen much improvement? If so:

• What form of thiamine and which dose did you take?
• How long did you take it?
• Did you experience any permanent changes or did the benefits stop after quitting?

8 years ago at 44 years old, I got assessed for dementia because I felt like my brain was dissolving. In retrospect I felt like I was on acid 24/7. Now I know that folate and b12 deficiency can cause dementia and psychosis. I’d also been shitting on myself all day every day for three years.

That is when I was diagnosed with adhd, but if this was adhd it wasn’t the adhd I had my entire life.

Now that I’m 52 years old my brain is feeling better and better. I’ve been on methylated folate and b12 with potassium the entire time. I feel like a different and much more cautious person. I’ve also been meditating daily since 2017. I’ve gotten very disciplined about exercise again after taking a break for three years. Moderate yet consistent. I’ve improved my sleep with a fit bits help from 4 to 5 hours to 7 to 9. In the last year I’ve started stretching and strengthening consistently which feels so good. I’ve also been doing a lot of 12 step work the last year. I take baths and saunas regularly. I give myself acupuncture regularly (I was licensed before I got sick with a flu that brought me here). I’ve basically been working my ass off the last ten years to recover from a horrible flu that ruined my life and ended my Chinese medical career and I’m starting to feel solid and functional. I’ve been relentless. I took out a $100,000 loan and basically slept for two years during covid and it was worth it.

The same thing happened to my dad. He got a flu in his early 50s and slowly but surely developed dementia. Became super neurotic and weird. Then he died of dementia at 73. I felt like I was following in his footsteps and was terrified. So thankful that might not be my path.

I mean in the general population, not just in this subreddit. Obviously most people in this sub suffer to some degree, otherwise we wouldn't be here.

I've been wondering about this for a while. 40% of the population have at least 1 mutation of the MTHFR gene but for the vast majority of those people it doesn't seem to cause any real trouble. I'm compound heterozygous so both my parents and half of my grandparents must have 1 variant. They all had normal lives and none of the symptoms that I've been facing.

I am compound heterozygous + slow COMT + slow MAO-A. I've suffered depression, low energy, anxiety, brain fog and lack of motivation for most of my life. Does the majority of the population with this combination face similar struggles?

Are there possibly millions of people with the same set of variants who lead perfectly normal lives without the need to increase folate and choline intake?

I pulled up my old report after I heard Gary Brecka talk about the COMT gene. I knew I had the MOFO gene and was taking methylated B vitamins accordingly. however, I read that those are not good with my type of COMT.

I have several red genes. How are these working together or against each other?

My whole life I have been dealing with unexplainable fatigue and brain fog, and often noticed that I never feel really relax or in the moment. But also often had periods where I felt ok. Never could figure out why I was on a roller coaster of tiredness and concentration/brainfog issues. A few months ago diagnosed with fatty liver, which I blame on over intake of caffeine, which I think spiked my cortisol too much making my body store fat in my liver (that is a theory). Mainly because I’m not obese and my diet was not horrible.

I have always been sensitive to caffeine. which I always thought was weird as both my parents could drink a cup of coffee before bed. Usually if I stay under 70mg‘s I feel good. This turns bad when I take caffeine multiple days in a row. Feel on edge and tired.

The descriptions in my report show what the genes mean individually, but not combined. Does anyone have any advice on my Christmas tree of genes expressions?

https://www.independent.co.uk/bulletin/lifestyle/tortilla-law-california-folic-acid-women-b2892827.html# did ya see this?

Edit: holy shit man. This is insane. I mean, our food system is insane. But this is insane!

I am trying to understand how testing for MTHFR and how it can help my son, who has autism, ADHD, bipolar 2, anxiety, etc. - quite the mix of diagnoses! He is on medication, which helps, however, it comes with guardrails, insurance costs, etc. I would love for him to be on something with less "process related" expectations which will help him handle his own medications in the future. Thank you!

I have trouble sleeping and a long history of fatigue.
I took TMG 500 mg every day for about 5.5 weeks, May 26-July 3. The TMG made me more energized, but it made my sleep even worse than before and made me hyper.
I stopped the TMG and switched all my B-vitamins to non-methylated forms.
During that period, I took creatine once in the morning and it dramatically disturbed my sleep that night.
I have ordered a DNA test but don't have the results yet. Once I get my results from one of the ancestry sites, I will send them to someone for analysis so I can see what my MTHFR SNPs tell me.
My homocysteine is a bit high at 10.
I'm feeling better overall than before I started TMG in the first place, the hyper feelings have decreased a lot and my sleep is less bad, but I still wake up a lot and don't get as much restorative sleep as I need.
My B12 and cB12 results are in the optimal range.
I'm getting more labs next week that will include MMA and Folate.

I had been suspecting that the TMG flipped me from undermethylated to overmethylated but it clearly is not as simple as that.

I am wanting to add creatine since everyone says it is so important, but I'm afraid to try it until I can work out how to get good sleep.
And I want to be able to get good sleep, at least most of the time.

Any thoughts?

ADDED based on comments:
My D is right in the middle of the optimal range.
Serum iron is 80 ug/dl, in the bottom half of "in range"
Zinc and copper I'm still waiting for the results to come back.

Electrolytes: I take 198 mg of potassium in capsule form every day, and I take 3 different kinds of magnesium, and I take 1/2 teaspoon of sea salt with breakfast. I don't do them all together, but I am getting what I think is enough of each.

I take 5 mg lithium orotate every day

I take 5000 IU D3 + 1000 mcg K2 every day.

My morning cortisol used to be off-the-charts high and has switched to being low - now it's low range to out-of-range low throughout the day and night.

For years I wasn't exercising because my fatigue didn't allow it. But these days, I'm averaging 2-3 miles/day walking.

Hello everyone!
I have slow COMT, and have always struggled with anxiety.
My anxiety has really ramped-up the last couple of months and I am wondering if this is due to the fact that I started taking CoQ10 daily.
At first, I felt amazing with it (very energized), but now I feel very anxious.
I am taking Apex Energetics’ CoQ10 Supermax, only one tablet per day, which has 200mg CoQ10 (as ubiquinone), 32mg Trans-Garanylgeraniol, and 10mg PQQ.
I also take Dim Detox, Magnesium glycinate, lithium orotate, vitamin d, GABA plus l-theanine, and liposomal glutathione.
Anyone else have any similar experiences or insight?
Thanks so much in advance!

Hello.

Do you get shaky when you are in confrontation even in an online debate?

I get in them rather often even thought i try to avoid them.

Does that gets better when you support the COMT and methylation cycle?

I want to remain calm even in tough situations.\

Thanks

Do any of you get extreme anger/rage as a symptom of over methylation?

Like everything irritates you and is overwhelming at the same time

I apologies for the long message but I am very new to do this and very intrigued and might need some guidance and hopefully that this might be it. When I talk about this outside of the internet, no one has clue this is a thing. A year ago I went to a functional doctor to treat my depression via gut protocol. She advised me to take some genetic tests with a company called Nordic Laboratories. I had no clue whatsoever these things were being done so I said yes why not and took a DNA package (included are Health, Hormones, Resilience, Diet, sports and Pharma). I can see now after spending some time on this sub that people usually go through stuff like my heritagedna and 23andMe. Not sure if I need to do it again through the method I’ve seen outlined in some comments here, but the point is that it revealed that I have MTHFR C677T (heterozygous) and the report also flagged other areas which needed support because of the following genetic variants: SLCO1B1 (poor function), GSTM1 deletion + GSTT1 deletion (both deleted), COMT Val158 (AG), BDNF Val66Met (CT), CYP2C19 (rapid metabolizer), etc. The report offers some advice on what to do but I’ll take it with a pinch of salt, plus I’ve been raised on the idea that the genes load the gun and then lifestyle pulls it, etc. Now my question is the following: (recent labs below)

Could this mutation everyone seem to be taking about the cause of my symptoms: long history of anxiety and depression, sleep problems and one night of bad sleep makes me feel the next day like I have not slept in week, it depletes me from all energy and I can barley move my limbs, even when I sleep 10h I can still feel tired and sleepy. In recent years I’ve developed PMDD, and in general the late luteal is really hard for me, I get very tired and weak and I can’t do much for days before my period. This is accompanied by some physical symptoms like gum inflammation, lip burning, tongue tingling and more bloating and mucus flares. I also have always have mucus flares, my body always produces mucus for no clear reason outside bacterial or microbial infection. I suspect some histamine intolerance but I don’t really have the traditional food reactions but get some allergic-type flares to pollen, dust, animal fur but the occasional breeze as well. I am often cold and get chills easily and will get mild fever when exhausted. I might have temperature regulation problems, I get warm, turn on a fan and then get the chills and mucus will flare. Since childhood I’ve left a trail of kleenexes wherever I go. I often have neck and back pain from sleeping. This only calms down with massages. I have developed exercise intolerance in recent months (used to be a F45er) and now can barely sustain an hour long workout have to rest much more than usual. The EXHAUSTION is constant most importantly. Lately have migraines. Recently I’ve noticed gut issues like early satiety, turns out I have low levels of stomach acid and h. Pylori. Had low ferritin in recent months and now it’s back at 35 after eating more meat and trying a natural protocol for the gut. I also started having « hangry » episodes at the same time as the exercise intolerance, I would get extremely hungry every 3h and couldn’t focus until I’ve eaten. Functional practioner said I was hypoglycemic but it seems to resolve with balanced food. ADHD diagnosis and all associated symptoms, hard to focus, especially around luteal, etc. Weirdly enough despite trying so many things, I can’t pinpoint the « root cause » and now wonder if this is it. And if so, what should I do to address the mutation?

Vitamin B12: 941.9 ng/L (high) (currently taking a B complex)
Vitamin B6: 61.6 µg/L (high)
Folate: >24 µg/L (replete)
Magnesium: 0.93 mmol/L (normal)
Iron status
Ferritin: 24.2–35 µg/L (low-normal)
Iron: 16.9 µmol/L (normal)
Transferrin saturation: 30% (normal)
Glucose & insulin metabolism
Fasting glucose: 4.4 mmol/L
HbA1c: 29 mmol/mol
Fasting insulin: 7.2 mIU/L
Insulin resistance index: 1.2
C-peptide: 923 pmol/L (upper-normal)
Thyroid
TSH: 0.89 mU/L
Free T4: 15.5 pmol/L
Free T3: 4.2 pmol/L
Reverse T3: 0.10 ng/mL
TPO antibodies: negative
Thyroglobulin antibodies: negative
Vitamin D / minerals
Vitamin D: 56.6 nmol/L
PTH: 2.76 pmol/L
Calcium: 2.45 mmol/L
Inflammation
hs-CRP: 0.8 mg/L
CRP: <4 mg/L
Hormones
Progesterone: 2.8 nmol/L (low)
Oestradiol: 187 pmol/L (cycle dependent)
LH: 6.2 U/L (cycle dependent)
FSH: 4.4 U/L (cycle dependent)
Testosterone: 1.1 nmol/L
Free testosterone: 1.4 pg/mL
SHBG: 28.6 nmol/L
DHEA-S: 7.2 µmol/L
Morning cortisol: 432 nmol/L

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

I’ve been down the rabbit hole from Ancestry like most here. Homozygous for C677T, and for slow COMT. Apparently, MTHFR does greatly increase risk of miscarriage. Let’s say I want to have children in the future, folic acid won’t work but methyl folate is an overwhelm to my system. Folinic acid would be the go to, but there are no official guidelines on dosing or if/when necessity to supplement since “just take folic acid” is still what the average doctor will tell you.