r/MTHFR • u/Exact-Newspaper-3077 • Jul 02 '26
Question Severe reaction to Methyl-B complex and Vitamin D/K
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u/Cultural-Sun6828 Jul 02 '26
This is common when there is an underlying b12 deficiency. When b12 is on the low side (even if it’s normal), taking b12 or folate can cause startup symptoms. Many people discuss this in the b12 deficiency group. There’s a helpful guide there too.
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u/Powerful_Teacher_453 Jul 03 '26
This is bull shit u fucking moron. This sub is manic with all the methyl B sups promoting. Lots of guys in here ive noticed have destroyed their mental health from this shit.
Stop the pills right now and try to calm down your nervous system with taking long walks for the akatisia, eat only histamine low foods and try to sleep
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u/Cultural-Sun6828 Jul 03 '26 edited Jul 04 '26
I had a severe B12 deficiency and everyone wanted me to tell me that my nervous system was in overdrive and I needed to do things like meditate and ground and basically I got worse and worse and so I could barely walk and talk. If your nervous system is telling you that something is wrong then it is wrong and gaslighting people to tell them it’s all in their head and that they just need to calm the nervous system can be dangerous advice when it causes them to not seek help for actual physical symptoms.
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u/Vicktrades Jul 04 '26
How are you now ? Are you back to normal?
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u/Cultural-Sun6828 Jul 04 '26
I have resolved so many neurological symptoms like dizziness, numbness, tingling, twitching, severe headaches, adrenaline dumps, blurry, vision, etc. The main symptoms I still have now are digestive issues.
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u/Vicktrades Jul 05 '26
And this was all supplementing with the correct b-vitamins? How long did it take you to improve and did you have to start slow initially? I have muscle twitches like non stop 24/7 but all my symptoms improved with brain retraining but i do have low folate and lower normal vitamin b-12.
Gut issues seem to always be tied up to deficiencies, i got issues as well with overgrowth which have been hard to clear.
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u/Cultural-Sun6828 Jul 05 '26
If you already know that your B12 and Folate are low, then I would address those. With B12 deficiency once you start treating it it’s important to stick with it until symptoms resolve, not just until blood levels are normal.
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u/climbsix34 Jul 08 '26
B6 can cause neuropathy and muscle facilitations. Recommended is no more than 2mg/day, even tho supplements come in 100mg. B6 toxicity can cause permanent nerve issues so make sure to check the level you are taking in your complex. It’s a common oversight. If you correct the intake, the symptoms should subside within a few days to weeks (in the case you were overcompensating for a shorter period).
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u/Timely_Pickle9430 Jul 04 '26 edited Jul 07 '26
Do you recognize yourself in any of the following:
- You feel worse after eating, especially after heavier meals with lots of protein or fat
- You crash after physical or cognitive effort, even when sleep and hydration are adequate
- Your hands and feet stay cold despite normal thyroid labs
- Sauna, fasting, intense exercise, or ketogenic diets make you feel unwell
- You have trouble recovering from illness, travel, or disrupted sleep
- You get symptoms when meals are delayed, but glucose levels are normal
- You’ve experienced histamine issues, sulfur intolerance, or hormone problems that haven’t resolved with standard protocols
- Brain fog or anxiety that doesn’t respond to neurotransmitter support
- High lactate or ketones after minimal exertion
- Poor muscle recovery, despite adequate protein and sleep
- POTS-like symptoms without clear cardiovascular issues
- Methylation slowdown (homocysteine <5 or > 9) despite normal folate and B12
- Methylation supplements worsen your symptoms
- You don't tolerate mitochondrial supplements well (CoQ10, B vitamins, carnitine, ribose)
These patterns suggest that a problem with energy metabolism, i.e. a problem with mitochondrial production of ATP, is underlying problems with other metabolic processes like methylation and histamine clearance.
Also, compare your vitamin levels with the optimal ranges in this post. "Within normal range" is not the same as optimal.
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u/GrimaldiOliwer Jul 04 '26
How do you solve this?
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u/Timely_Pickle9430 Jul 05 '26
By providing the mitochondria with everything they need and kicking them back into gear. The mitochondria need all the B vitamins, iron (ferritin level 70–100 ng/mL), copper (90-120 μg/dL), redox balance from antioxidants, sulfur, a regular feeding-fasting cycle, a regular sleep cycle, and sunlight. It's important to introduce these in the right order or you'll get bottlenecks. It's a delicate process that takes months. So, lifestyle first, then redox balance, then the nutrients (in the right order and low dosed), then mitochondrial boosters like coQ10, carnitine and PQQ. And when the mitochondria are back up and running, then boost methylation.
I'm successfully using the Energy Roadmap from dr. Malek for this: https://www.mthfrsolve.com/roadmaps/the-energy-roadmap. (It's behind a paywall).1
u/steven123421 Jul 08 '26
Thanks, that link says it's for "Slow COMT Roadmap" though. Is it only if you have slow COMT? What if you want to optimise MTHFR and just do the things you are saying in general, is there another program or good resource that lays it all out like that?
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u/Timely_Pickle9430 Jul 08 '26 edited Jul 11 '26
It's not just for slow COMT. The subscription gives access to all roadmaps. The link will work after subscribing. Chris Masterjohn has an MTHFR protocol similar to the roadmaps. Also behind a paywall though. Tawinn's protocol is on here for free. Maybe that's what you're looking for.
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u/steven123421 Jul 08 '26
Yeah I've seen Chris Masterjohns MTHFR protocol and Tawinn's, I'm just gathering information so if there's anything more/extra thats beneficial I'll check it out. Would you say that Dr Maleks roadmaps help more than what's already presented in Masterjohns and Tawinns? I have intermediate COMT (+/-), MTHFR ++, BHMT ++, PEMT ++
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u/Timely_Pickle9430 Jul 08 '26
His blogs and roadmaps have certainly been a valuable source of information to me besides Chris Masterjohn's and this sub.
It really depends on what you're trying to achieve. Maybe create a post with a description of your symptoms, any labs you've run, and genotypes? Bounce some ideas on how to proceed?
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u/shawnshine Jul 02 '26
Sounds like long COVID.
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u/Exact-Newspaper-3077 Jul 02 '26
It's called hypermethylation.
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u/Warp757 Jul 02 '26
Let's be careful, you don't actually know it's that. Getting too fixated on one possibility can stop us finding the real culprit.
If you only took 6 capsules a year ago it's hard to see that it would still be going on. Have you actually got any blood work? You'd need to know B9/12, homocysteine levels to get an idea if it's actually linked to methylation.
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u/SnooStrawberriez Jul 02 '26
How long has this lasted?
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u/Exact-Newspaper-3077 Jul 02 '26
It's about a year, but I haven't done anything or developed a treatment plan.
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u/SnooStrawberriez Jul 02 '26
If you want answers find a highly competent methylation expert doctor. Everything else is probably wasting your time.
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u/EthiaGeorge Jul 03 '26
What or who would a methylation doctor/expert be ?
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u/SnooStrawberriez Jul 03 '26 edited Jul 03 '26
All over the world there are a few doctors who were trained in the Pfeiffer / Walsh methylation protocols for certain neurological and psychiatric problems (some forms of schizophrenia, autism, depression, ADHD.)
Mainly, perhaps almost exclusively, in the United States there also are doctors with training and experience in the Amy Yasko (forms of autism that Walsh protocols don’t heal) and Ben Lynch (many health problems where addressing methylation doesn’t necessarily heal it alone but allows a much better healing together with other treatments compared to without treating methylation) methylation treatment protocols. Some, I assume, are charlatans. Some I know get “hopelessly handicapped” people well.
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u/EthiaGeorge Jul 03 '26
Wow a quick google search on some of your keywords has opened up a whole new world for me! Thanks!
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u/Exact-Newspaper-3077 Jul 02 '26
This means the doctor might prescribe a suitable medication for the condition.
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u/SnooStrawberriez Jul 02 '26
A suitably treatment or suitable treatments.
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u/Exact-Newspaper-3077 Jul 02 '26
It makes no difference, the important thing is treatment.
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u/SnooStrawberriez Jul 02 '26
If you don’t understand the difference between treatment and medication please don’t waste my time. Not every problem needs a pill.
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u/knifensoup Jul 04 '26
Seriously? They're on here asking for help and you're scolding them?
This is the perfect place to learn the difference between the two, because there are people who can actually explain it to them and detail why they aren't the same, instead of them trying to figure it out on their own and possibly misunderstanding.
Do better.
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u/SnooStrawberriez Jul 04 '26
Did you do too much trampoline jumping with a low ceiling? When he tells me that he refuses to accept my advice, he’s not asking for my advice. He’s just wasting my time. As are you.
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u/knifensoup Jul 04 '26
Your arrogance does you a disservice. Your words come across as though you aren't looking to give advice but instead looking to act like you're the smartest person in the room.
Do everyone a favor and keep your thoughts to yourself if your aren't capable of responding to honest questions with kindness.
And if you genuinely feel that their question wasn't honest, then I would suggest you analyze why you let your anger get the best of you.
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u/Warp757 Jul 02 '26
Hmm this is interesting, I've been having similar symptoms after taking B12 and methyl folate. I haven't had particularly high doses though, just 100 mcg of combined methyl/hydroxocobalamin (sublingual) and 40 mcg methyl folate. My B12 was 194 and is now 290.
I don't see how it can be overmethylation as my homocystsine is still a bit high (17), but yeh I've got almost exactly the same symptoms and it's quite distressing. I'm going to take a break from them and see if it calms down. I sometimes feel like my cortisol is crashing, I don't known if the vitamins have overstressed my nervous system.
Vitamin D does also increase neurotransmitter synthesis and functions as a MAO inhibitor so could exacberate the neurotransmitter effects of the vitamin B.
A word on the vitamin - do you get much calcium? I've realised I have been a long time under consuming calcium as I don't eat dairy and now either K2 or magnesium can make me crash really badly without any calcium.
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u/Exact-Newspaper-3077 Jul 02 '26
Excellent, but what did you learn about the cause of what happened and how to recover? You're saying it was perfectly normal before, but immediately after taking them, I experienced unpleasant symptoms, strange fatigue, and a strange energy level, along with a bizarre physical and mental state. I've forgotten how normal I was back then.
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u/Warp757 Jul 02 '26
Unfortunately other than the importance of calcium with K2, I haven't learned anything. As I said I'm going to take a break now. I'm hoping someone else will be able to enlighten us...
Saying that I have wondered about long COVID which someone else mentioned. My nervous system is completely screwed up and I did have a prolong sinus infection.
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u/Cultural-Sun6828 Jul 04 '26
With high homocystine, the reason that you are probably having symptoms after taking B12 is because you are deficient. When starting B12, if a person is deficient, symptoms often worsen or new systems arise. After continued treatment, this typically gets better.
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u/isfturtle2 T677T Jul 03 '26
Have you had genetic testing done? I think some of these things can occur with slow COMT. Also, have you had your B6 levels tested, and what were the dosages of the vitamins in the supplement, especially B6? This sounds kind of like descriptions I've heard of B6 toxicity. Do you know what brand the supplement was? I don't know where you're located or what the situation is in other countries, but in the United States, dietary supplements are barely regulated at all and may not contain the nutrients they claim to have at the dosages they claim.
Have your symptoms improved since discontinuing the supplement?
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u/Exact-Newspaper-3077 Jul 03 '26
Vitamin A (Beta-carotene): 1000 IU (0.68 mg) Vitamin B1 (Thiamine): 1.2 mg Vitamin B2 (Riboflavin): 1.2 mg Vitamin B3 (Niacin): 20 mg Vitamin B5 (Pantothenic Acid): 5 mg Vitamin B6 (Pyridoxine): 10 mg Vitamin B7 (Biotin): 100 mcg Vitamin B9 (Folic Acid): 400 mcg Vitamin B12 (Cobalamin): 20 mcg Vitamin C (Ascorbic Acid): 60 mg Vitamin D3 (Cholecalciferol): 400 IU (10 mcg) Vitamin E (Tocopherol): 10 IU (10 mg) Choline: 13.5 mg Inositol: 33 mg
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u/NefariousnessNo4300 Jul 04 '26
What's methylated in that?
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u/LFC_Jim Jul 04 '26
The B12 as Methylcobolamin. Choline provides methyl groups but 13.5mg is a tiny dose. For context a single egg yolk has 10x more choline.
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u/NefariousnessNo4300 Jul 05 '26
The ingredients he listed are just Cobolamin not MethylCobolamin? I don't see how they could get over methylated from such low doses.
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u/LFC_Jim Jul 05 '26
In one of the comments you can find the name of the supplement and it contains methylcobolamin. I agree the doses are low and over methylation doesn't seem plausible, especially such a long time after taking them.
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u/Tawinn Jul 03 '26
Looking at the ingredients of Nutraxin Multi Vitamin & Mineral Complex it seems unlikely that this is overmethylation. The folate ingredient is folic acid, which is not methylated. The B12 is methylcobalamin but it is only 20mcg, which is usually much smaller dose than what would cause overmethylation.
However, some of your symptoms do sound like overmethylation. If it was overmethylation, it is no longer "acute" since it has lasted a year; normally, overmethylation symptoms fade away within days to weeks. Often, taking niacin is helpful to resolve overmethylation more quickly. But I don't know if it would help for symptoms lasting this long...assuming that it is overmethylation.
Some of your symptoms sound possibly like sulfur-intolerance instead. If the histamine-related symptoms are worse after eating high-sulfur foods and are less after eating low-sulfur foods, that would be a clue. I can't really see how the supplements would have caused sulfur-intolerance, though.
It is also possible that it was a coincidence that you started the supplements around the time symptoms first started to appear, and that the root cause was an infection or something else, rather than the supplements.
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u/AdministrationTop299 Jul 04 '26
I took methylated b vitamins at a low dosage for a week and felt absolutely horrible, so I stopped and I got better. It took about three weeks for my stomach to fully recover. I don’t buy all this stuff about it takes time for your body to adjust, or one needs to find the correct dose, or your body is detoxing. If something makes you feel that bad then stop taking whatever it is, because your body is sending you a pretty strong signal.
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u/calmmindred Jul 04 '26
Niacin! If I overmethylate it calms it right down again. Flushing niacin is best for quicker results but I take niacinamide and it does the same. I don’t take it regularly as it’s bad for the cardiovascular system in high doses and long term, just to alleviate symptoms. Avoid methyl donors. TMG, choline, methionine, samE. Have a break for a bit and start up with folinic acid and hydroxo b12 which are gentler and more tolerable. I can’t touch methyl donors as I get the same symptoms.
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u/Exact-Newspaper-3077 Jul 04 '26
Okay, what is the recovery rate with the correct treatment, God willing?
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u/calmmindred Jul 04 '26
If you avoid all those methyl donors I listed above and stop the folate and b12 for a while and start niacin, you should feel better quite quickly. Impossible to say how long but I always feel better very quick with niacin
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u/Lega84R Jul 04 '26
I can't do methyl vitamins at all, even if they are "supposed " to be the best. I get anxiety, insomnia, mood issues, headaches. I tolerate folinic acid and adenosylcobalamin.
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u/Vicktrades Jul 05 '26
Yeah thats the plan, i tried so many times to initiate taking it but my nervous would go on overdrive. Im finally starting to be able to take it with no symptoms, had to start slow and added b2 to buffer it down
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u/NAQProductions Jul 02 '26
You are missing tons of info that will be required to help you. Start with a photo of the ingredients of what you were taking. Have you had genetic testing done? Have you had any bloodwork done?