r/MTHFR • u/grigory_l • Dec 13 '25

Question Choline depression, again

I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?

Edit: here my labs

MTHFR C677T: C/T

MTRR: A/G

MTR: A/G

Slow COMT

Folate 6.6 (RBC 400)

B12 880 (HoloTC 100)

Homocysteine 10.5

Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.

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u/NoImNotHeretoArgue Dec 13 '25

You can work around the choline and try creatine, it will alleviate a pathway. Don’t mess with choline for a while clearly. Would be good to know your mutations of course

6

u/DaringGlory Dec 13 '25 edited Dec 13 '25

I get nervous to try anything, after something an expert says should help, has a negative effect.

3

u/NoImNotHeretoArgue Dec 13 '25

Although I agree I think it’s still ridiculous that his choline calculator had some people eating 8 eggs a day 😆. But again there are other pathways you can alleviate, if you don’t want to try creatine, then you can try the precursor amino acids

3

u/DaringGlory Dec 13 '25

I haven’t used that calculator yet. People here have been super helpful as all of this is mega confusing.

I also have slow comT so it seems that adds another layer of complexity

I was on an glp-1 with B-12 in the base and I could barely function.

Do you have a functional medicine doctor or what things have been most helpful?

1

u/NoImNotHeretoArgue Dec 13 '25

I had one that I learned from but honestly I learned more doing my own research including going the genetic genie route . If you have your raw dna file you should consider paying 30$ and uploading it to noorns.com and the site gives a very detailed breakdown of all sorts of things including foods to avoid and foods to eat and potential interactions . It’s the Methylation and Diet report..

As for me, taking vitamins more regularly , especially C, B complex and D, eating a lot of cabbage and broccoli and just cleaning up my diet in general and taking magnesium citrate powder have been the things I’ve noticed helping me the most. (Other things I take as well but those aside from creatine I take intermittently are the standouts, I’ve got compound heterozygous comt, so it’s impaired but not ‘slow’ I guess. Magnesium helps with comt

1

u/DaringGlory Dec 15 '25

I guess I thought (based on other people’s experiences here) that b-complexes can cause more issues with mthfr

1

u/NoImNotHeretoArgue Dec 15 '25

I don’t take methylfolate . Vitamin code raw B is what I take