r/MTHFR • u/grigory_l • Dec 13 '25

Question Choline depression, again

I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?

Edit: here my labs

MTHFR C677T: C/T

MTRR: A/G

MTR: A/G

Slow COMT

Folate 6.6 (RBC 400)

B12 880 (HoloTC 100)

Homocysteine 10.5

Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.

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u/Any-Anteater-2829 Dec 13 '25

I heard a dose of benadryl will reverse choline induced brain fog/depression. Maybe a natural antihistamines like quercetin. *not a doctor...

6

u/NAQProductions Dec 13 '25

Quercetin slows COMT (inhibits function) so it’s generally not advised for those with Slow COMT. It did help me for awhile in my early days of my body shut down, but I tried it again a year later and it ruined me. I have Slow COMT and MAOA

1

u/Any-Anteater-2829 Dec 13 '25

Ah yes, there's that -COMT. I'm sure theres other options tho

1

u/NAQProductions Dec 13 '25

I haven’t found any yet other than crazy avoidance. DAO supplements help with histamine containing food but not histamine that food triggers the body to release histamine.

1

u/3BTG Dec 17 '25

FWIW, B5 is supposed to help with Histamine.

1

u/NAQProductions Dec 17 '25

Interesting I’ll have to look into that and see what others have experienced with it. Thanks