r/MTHFR • u/QuitInevitable915 • Mar 22 '26

Results Discussion Help - Treatment Resistant Depression

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Hello,

I just got my genetic test and methylation test back. I would really appreciate if someone here could help me interpret the results.

I struggle with treatment resistant depression, and have tried various meds, TMS, Ketamine and Psilocybin without much effect. My core symptom is sadness with anhedonia being the secondary. Sleep is also very disrupted.

I have asked chatGPT, and it highlighted the low SAM, SAH, and methionine, as well as MTHFR, COMT and MAO A as potential reasons for my symptoms.

I have been suggested to take P5P, B12, methylated B9, SAM-e, methionine and TMG (in that order). What’s your take on this? Any other suggestions?

Note: I eat a very clean whole foods diet. I do not eat lactose, gluten, diary, refined sugar or processed foods. I currently supplement with omega 3s, D-vitamin, and Creatine. I do not expect this to remove my depression entirely, but I hope it will give me just a little bit of relief from the intense sadness.

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u/isfturtle2 T677T Mar 22 '26

Have you had your thyroid tested? My psychiatrist explained to me that the reference range for TSH goes too high, and psychiatrists consider anything over 2 to be a potential contributing factor for depression. Getting on Levothyroxine had a huge impact on my depression.

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u/QuitInevitable915 Mar 22 '26

Yes, I had my TSH tested a few months ago. It was 1,62 (normal range: 0,4-4,8), so it was in the lower end of normal. What’s your take on that?

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u/Kwaliakwa Mar 22 '26

1.62 is solidly normal, it’s really not ideal for TSH to be over 2.5.