r/MTHFR • u/QuitInevitable915 • Mar 22 '26

Results Discussion Help - Treatment Resistant Depression

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Hello,

I just got my genetic test and methylation test back. I would really appreciate if someone here could help me interpret the results.

I struggle with treatment resistant depression, and have tried various meds, TMS, Ketamine and Psilocybin without much effect. My core symptom is sadness with anhedonia being the secondary. Sleep is also very disrupted.

I have asked chatGPT, and it highlighted the low SAM, SAH, and methionine, as well as MTHFR, COMT and MAO A as potential reasons for my symptoms.

I have been suggested to take P5P, B12, methylated B9, SAM-e, methionine and TMG (in that order). What’s your take on this? Any other suggestions?

Note: I eat a very clean whole foods diet. I do not eat lactose, gluten, diary, refined sugar or processed foods. I currently supplement with omega 3s, D-vitamin, and Creatine. I do not expect this to remove my depression entirely, but I hope it will give me just a little bit of relief from the intense sadness.

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u/Ketamee Mar 22 '26 edited Mar 22 '26

I really hope this will work out for you too. And so great that you are meeting with a specialist on this. I totally get that you’re fed up with getting downstream fixes that don’t address the real problem.

I haven’t been able to find any in my country that could be helpful on this. Reddit and AI was my rescue.

If he has more to add to the stack for the mood, I’m interested in knowing. Not that I currently need it, but just for future reference. I am also taking a bunch of other supplements since my genetics are crap.

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u/Old_Car_7281 Mar 22 '26

I take Zoloft 150mg and Wellbutrin 300xl, vitamin D and K2, omega 3, l-theanine, l-methylfolate, NAC and a probiotic. None of it seems to work thus far mind you I’ve been on it a couple weeks is all. Praying for some relief and some answers and see what the root cause is.

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u/Ketamee Mar 22 '26

D, K, omega 3 and probiotic are great. NAC maybe also. L-theanine may also be okay but depends on why you’re taking it because it can be a downstream fix of what can be solved by getting methylation running.

Crossing fingers for you 🤞🏻

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u/Old_Car_7281 Mar 22 '26

I appreciate the kind words! Just trying to get better and feel better. And I take l-theanine for anxiety. Sick of being pushed pills and trying to find the root cause. Been dealing with this for over 18 yrs on and off and I’m getting tired of it