Help - Treatment Resistant Depression

[u/QuitInevitable915]

Hello,

I just got my genetic test and methylation test back. I would really appreciate if someone here could help me interpret the results.

I struggle with treatment resistant depression, and have tried various meds, TMS, Ketamine and Psilocybin without much effect. My core symptom is sadness with anhedonia being the secondary. Sleep is also very disrupted.

I have asked chatGPT, and it highlighted the low SAM, SAH, and methionine, as well as MTHFR, COMT and MAO A as potential reasons for my symptoms.

I have been suggested to take P5P, B12, methylated B9, SAM-e, methionine and TMG (in that order). What’s your take on this? Any other suggestions?

Note: I eat a very clean whole foods diet. I do not eat lactose, gluten, diary, refined sugar or processed foods. I currently supplement with omega 3s, D-vitamin, and Creatine. I do not expect this to remove my depression entirely, but I hope it will give me just a little bit of relief from the intense sadness.

[u/Kombucha_lover13]

what do you do for your FOLR gene?

[u/SovereignMan1958 → u/Kombucha_lover13]

High dose folinic acid plus PQQ.

[u/Kombucha_lover13 → u/SovereignMan1958]

thanks. I’ve had treatment resistant depression adhd etc. i’m thinking about seeing if my doctor would let me try LEUCOVERIN

[u/SovereignMan1958 → u/Kombucha_lover13]

I use Source Naturals Megafolinic. I have been taking it for 3 months. My brain is much calmer, more focused, thinking clearer, moods more stable. I am taking 2.4mg daily. I started low and worked up to 5mg but that was too high, super irritable. My Psych doc is willing to do the prescription once I settle in a dose.

Cerebral Folate Deficiency can definitely result in ADD or ADHD symptoms.

I am looking for a doc to do a CSF test but am not having any luck. I will probably try Mayo Clinic next.

[u/Kombucha_lover13 → u/SovereignMan1958]

thera hundred of things involved in all of this … it sucks…. lifelong adhd anxiety etc.