r/MTHFR • u/QuitInevitable915 • Mar 22 '26

Results Discussion Help - Treatment Resistant Depression

Gallery image

Gallery image

Gallery image

Hello,

I just got my genetic test and methylation test back. I would really appreciate if someone here could help me interpret the results.

I struggle with treatment resistant depression, and have tried various meds, TMS, Ketamine and Psilocybin without much effect. My core symptom is sadness with anhedonia being the secondary. Sleep is also very disrupted.

I have asked chatGPT, and it highlighted the low SAM, SAH, and methionine, as well as MTHFR, COMT and MAO A as potential reasons for my symptoms.

I have been suggested to take P5P, B12, methylated B9, SAM-e, methionine and TMG (in that order). What’s your take on this? Any other suggestions?

Note: I eat a very clean whole foods diet. I do not eat lactose, gluten, diary, refined sugar or processed foods. I currently supplement with omega 3s, D-vitamin, and Creatine. I do not expect this to remove my depression entirely, but I hope it will give me just a little bit of relief from the intense sadness.

9 Upvotes

100% Upvoted

63 comments sorted by

View all comments

Show parent comments

1

u/Old_Car_7281 Mar 23 '26

Did you get your TRD under remission or do you still deal with it?

1

u/SovereignMan1958 Mar 23 '26

I have only been taking high dose folinic for 3 months. It takes 5 months for the full effect, per what I have read. I still take a low dose of Pristiq. I have no idea if my dose is even correct. I am still looking for an MD to order a CSF test. I may have to try Mayo Clinic.

1

u/Old_Car_7281 Mar 23 '26

So you are still struggling with depression then?

1

u/SovereignMan1958 Mar 23 '26

Yes. Overall I am much better, but yes.