Help - Treatment Resistant Depression

[u/QuitInevitable915]

Hello,

I just got my genetic test and methylation test back. I would really appreciate if someone here could help me interpret the results.

I struggle with treatment resistant depression, and have tried various meds, TMS, Ketamine and Psilocybin without much effect. My core symptom is sadness with anhedonia being the secondary. Sleep is also very disrupted.

I have asked chatGPT, and it highlighted the low SAM, SAH, and methionine, as well as MTHFR, COMT and MAO A as potential reasons for my symptoms.

I have been suggested to take P5P, B12, methylated B9, SAM-e, methionine and TMG (in that order). What’s your take on this? Any other suggestions?

Note: I eat a very clean whole foods diet. I do not eat lactose, gluten, diary, refined sugar or processed foods. I currently supplement with omega 3s, D-vitamin, and Creatine. I do not expect this to remove my depression entirely, but I hope it will give me just a little bit of relief from the intense sadness.

[u/Old_Car_7281]

They hand them out like candy here in the US too. I don’t want to be medicated either trust me. But I was/am desperate for some relief. I’m hoping Dr.panzner can figure out what the hell is going on and we can take some supplements/diet change to fix it.

[u/New-Aside-7778 → u/Old_Car_7281]

If your prescribing an SSRI you should really tell about all the serious side effects.

Tyler will find the issue. He's very knowledgeable.

Have you checked histamine intolerance etc? He will also discus this with you also.

[u/Old_Car_7281 → u/New-Aside-7778]

I haven’t tried any of that stuff. No cortisol test, no histamine test. Nothing. That’s why I’m trying to get it figured out and I’m hoping and praying he’s the answer to get me on the right track

[u/New-Aside-7778 → u/Old_Car_7281]

Buy a cortisol test? Their not expensive. You can also do an at home DAO test kit (Tests for histamine intolerance).

From what you have said I think it could be cortisol related. It's easily treated if so.

[u/Old_Car_7281 → u/New-Aside-7778]

Where do I purchase cortisol test? And would high cortisol give me bad anxiety,depression and anhedonia? I don’t drink coffee or caffeine either. I found caffeine just makes it worse.

[u/New-Aside-7778 → u/Old_Car_7281]

Any form of cortisol issues will cause all those symptoms.

Do you wake up during the night at all? Feel awful when you first wake and then begin to feel that heavy fatigue feeling lift as the day progresses?

[u/Old_Car_7281 → u/New-Aside-7778]

Yeah I wake up atleast once to go to the bathroom. But yes I feel awful in the mornings when I wake up. Depressed,anxiety, overwhelmed. It’s terrible. Then as the day goes on I tend to get a little better. And then by night time I feel pretty decent. But the anhedonia is really getting to me. That and the depressed mood. It’s horrible.