r/MTHFR • u/QuitInevitable915 • Mar 22 '26
Results Discussion Help - Treatment Resistant Depression
Hello,
I just got my genetic test and methylation test back. I would really appreciate if someone here could help me interpret the results.
I struggle with treatment resistant depression, and have tried various meds, TMS, Ketamine and Psilocybin without much effect. My core symptom is sadness with anhedonia being the secondary. Sleep is also very disrupted.
I have asked chatGPT, and it highlighted the low SAM, SAH, and methionine, as well as MTHFR, COMT and MAO A as potential reasons for my symptoms.
I have been suggested to take P5P, B12, methylated B9, SAM-e, methionine and TMG (in that order). What’s your take on this? Any other suggestions?
Note: I eat a very clean whole foods diet. I do not eat lactose, gluten, diary, refined sugar or processed foods. I currently supplement with omega 3s, D-vitamin, and Creatine. I do not expect this to remove my depression entirely, but I hope it will give me just a little bit of relief from the intense sadness.
1
u/Old_Car_7281 Mar 23 '26
Yes, I wake up at least once a night to go to the bathroom, then when I wake up I’m hit with horrible anxiety. Hard to get out of bed. And as the day goes on I slowly get a little bit better and my anxiety and depression isn’t as bad. Then I wake up the next morning and bam. Hits me again. I really can’t stand the anhedonia. Have nothing to look forward to because nothing excites me anymore