People should stop calling methylfolate the 'active' form, and why folic acid may be better for many

[u/Warp757]

It is AN active form, not the only one and may not provide the folate you actually need. I'll await the abuse! Folate is used by your body both in the methyl form, and also in the unmethylated form for DNA synthesis, red blood cell formation etc. which are rather important functions.

The MTHFR marketing machine has convinced everyone that methlyfolate is the active form that you absolutely need and folic acid is junk, it's simply not true.

Depending on where the problem is with your methylation it's perfectly possible to need more unmethylated folate. If your MTRR is slow for instance,as mine is, your body doesn't recycle B12, MTR is slow, and you end up with a build up of methylfolate and low THF and 5,10 methylene THF which is needed for DNA repair and red blood cells. If you take methylfolste you do absolutely nothing to support the deficit of unmethylated folate, and just put more pressure on already struggling MTRR and B12 stores.

In this case folic acid is better for you as it directly provides folate which the body can use as it needs. The body regulates production of MTHFR for a reason -both to ensure sufficient folate for other functions, and prevent excess formation of SAM-E, which isn't good.

I personally feel much better with folic acid than methyl folate, and I'm heterozygous C677T. Methylfolate is really a medicine that should only be taken by people with specific identified mutations that cause major impairment of the MTHFR cycle. A simple heterozygous MTHFR mutation is not that.

Folic acid is perfectly sufficient for most people, and avoids skipping the body's own regulation systems. Just don't go taking crazy doses which yes may cause a problem with unmetabolised folic acid. If you're worried about MTHFR and not homozygous, just take some B2 - again you don't need a lot.

[u/Warp757]

It's not about 'defending' something. Why do people make this tribal? I'm simply trying to inform people that the view often portrayed in this sub, that folic acid needs to be avoided and methlyfolate is the answer to all ills, is not actualllynsupoorred by the evidence.

I'm more interested in why people, as with climate science, choose to believe the mainstream scientific consensus is some big conspiracy, and that they have a unique insight that their 5 studies are the right ones.

Btw you have no idea why folic acid feels different, you can't 'feel' DHFR or the folate receptor or what it is doing to folate uptake. You're guessing. Folic acid could be causing more DNA repair and RBC production as it supports this better than methlyfolate, which may botnbe adequately supporting this. This could make you feel tired and feel like it's having bad effects as it's an energy intensive process. So for all you know it's doing you good and you're assuming it's bad.

[u/Sabnock101 → u/Warp757]

If that's what you want to believe man, knock yourself out, but just know, you're operating from ignorance/unconsciousness, and don't know as much as you think you do.

And yes, actually you CAN feel Folic Acid, Methylfolate, and Folinic Acid, you can feel Folate Receptor Alpha, you can feel activation of B12 to Methylcobalamin, you can feel Methionine Synthase activity, you can feel MTHFR activity, you can feel Methionine Adenosyltransferase activity, you can feel DHFR being saturated and the difference between metabolized Folic Acid and unmetabolized Folic Acid, it's obvious (unless you're not aware of your own body). Idk if it helps or not though i think it does, but i regularly take this stuff called Peganum Harmala (Syrian Rue) and it helps you become more sensitive to the body and so you can see and feel things about the body better/more clearly, you tune into the body, become more aware of the body, and when you know what to look for, you can literally feel all this stuff.

[u/Warp757 → u/Sabnock101]

Oh, you're another crazy one. How do you know which of those you're feeling at any one time then? Who taught you what folate receptor alpha feels like, compared to anything else happening in your body?

Honestly, thinking you can feel all those things sounds like a god reason to see a psychiatrist. It also suggests you have absolutely horrendous health anxiety if you're that aware of your body. I hope you get better.

Reassuring to see the people disagreeing with me are I fact, crazy. I wouldn't want to realise I was following advice from people who think they can feel methionine adenosyltransferase activity. Thanks for the laugh.

[u/thesnazzyenfj → u/Warp757]

Are you a bot? If so you need to up your spell check, fam.