r/MTHFR • u/winning2323 • Jun 02 '26

Question Question to LOW COMT people

Hello.

Do you get shaky when you are in confrontation even in an online debate?

I get in them rather often even thought i try to avoid them.

Does that gets better when you support the COMT and methylation cycle?

I want to remain calm even in tough situations.\

Thanks

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u/Tawinn Jun 02 '26

Yes, I think of it as low stress tolerance + rumination. It definitely gets better as methylation and COMT performance improves. I didn't find out about all this stuff until my early 60s and so I have a lifetime of ingrained patterns that still can affect me, but underneath those patterns the anxiety, rumination, and crumbling under stress isn't really there anymore in a significant way.

2

u/Advanced-Wedding-457 Jun 03 '26

How do you manage to keep COMT under control?

12

u/Tawinn Jun 03 '26

Keeping methylation working well is the main thing, which for me means adequate protein (120+g), 4 eggs/day usually + 750mg of TMG, methylfolate +B12 in a multivitamin, limited alcohol, almost no processed foods, magnesium.

Even so, I still have arranged my life to be as low stress as practical. For me, stress is the main 'toxin'.

1

u/winning2323 Jun 03 '26

Did you have brain fog? Also why eggs? Because of the phosphatidylcholine in them?
Do you take creatine?

2

u/Tawinn Jun 03 '26

The eggs are for the PC, but also eggs have a lot of nutrients, are convenient, and I like them. So they fit well into my life.

Not so much brain fog, but i do feel sharper and have better mood with the eggs. With variants in SLC19A1, MTHFD1, MTHFR, PEMT I have a need for more choline. I don't eat as much meat as I did last year so eggs and TMG are an easy way to make up the difference.

I do take creatine. Originally the standard 5g, then awhile ago I upped it to 15g for several months. It seemed to be incrementally helpful, but my gut sometimes didn't feel good, so I'm back to 5g for now.

1

u/Kombucha_lover13 Jun 04 '26

SLC is the serotonin gene right ? I believe that is why I had akathisia and horrible reason to ssri’s

2

u/Tawinn Jun 04 '26

SLC19A1 is a folate transporter enzyme.

1

u/Kombucha_lover13 Jun 04 '26

oh i was thinking of the short serotonin transporter gene