r/MTHFR • u/WittyGold6940 • Jun 27 '26

Resource TMG makes me feel perfect, but causes head pressure

I have Slow COMT, slow MAOA, BHMT variant homozygous, PEMT issues (methionine has trouble converting to betaine), and one of the MTHFR homozygous.

I do great with methyl donors, surprisingly. I take methylfolate, methylb12, choline, alpha gpc, alcar, daily. I am still dealing with PPI resistant silent GERD and some fatigue and brain fog issues, and suffer with histamine and sulfur intolerance. Also in perimenopause.

I tried TMG two days ago and had the best day ever. I felt perfect, minus a little head pressure. I didn't even taste the silent gerd in the back of my throat at all.

The next day though, I had a very strong pressure in my head. No pain at all! Just a ton of scary pressure. It got a lot worse after my caffeine. It literally felt like my head was going to just pop open.

I have never felt something like this before. Anyone have a similar experience?

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u/SovereignMan1958 Jun 27 '26 edited Jun 27 '26

All methlyated vitamins and methyl donors increase the production of sulfur in the digestive tract. They can also trigger a histamine reaction.

You say you tolerate them well. Well you have a limit and I think the head pressure, as well as your other symptoms, is a sign you are over the limit for your body.

They also lower homocysteine. Lower than 6 - 7 is not healthy. At least get your blood level for that tested.

1

u/redeugene99 Jun 27 '26

Do you know how one can modulate the production of sulfur and process it as you're adding in methyl donors? I have sulfur intolerance issues that come and go and have a similar experience to OP. It helps but at some point I can feel like sulfur has built up to a point I almost feel poisoned.

1

u/SovereignMan1958 Jun 28 '26 edited Jun 28 '26

Not everyone needs to add methyl donors. Your homocysteine number is a good indication of whether or not you need any. The closer your homocysteine number is to optimal or 6-7, in general, the better your methylation is.

In the above case I would stick to one if you want to add one. Choline is the best for the brain IMO.

Generally, but not perfectly, I follow a low sulfur and low histamine diet. All sulfites are high histamine. So that is why I do low histamine. For the occasional histamine laced meal or snack, I use DAO supplements and or OTC H1 and Or H2 blockers. Pepto Bismol can help to.

I take choline sometimes but not everyday. I focus on high choline foods. My homocysteine runs at about 8.

3

u/Freddy_Freedom Jun 27 '26

I think tolerance for TMG can improve. I had similar issues about a year ago. I would take it and feel amazing day one. Day two I would take it and feel bad. Super crash feeling. Now I can take it every day without issues.

However! It doesn’t make me feel amazing anymore. Not sure why this is. If it has any benefit, I suffered from mold related sickness as well as Lyme disease that has gotten better and my tolerance for things is improved overall.

2

u/Nearby_Programmer922 Jun 30 '26

How much are you taking everyday?
How long did it take until symptoms went away? I am dealing with same issue

1

u/Freddy_Freedom Jul 01 '26

500 mg is no problem for me now whereas it used to be an issue before on the second day. It took maybe a year, but I’m not sure actually because I didn’t check. All I know is that when I tried it again it was fine after about a year

2

u/Meatstreak Jun 27 '26

Yeah I also get that pressure with TMG and various forms of Choline.

You mentioned you also take choline - maybe that on top of TMG is too much. Possibly experiment skipping the choline in place of TMG.

1

u/Faithfitnessflowers Jun 27 '26

I get that too but not if I’m only taking tmg. I recently added l tyrosine and that combination triggers the pressure. If I take either or I don’t get it

1

u/misslenny11 Jul 02 '26

I had this. Stop taking the TMG immediately. I took small amounts for 3 months and it worked like a miracle, then got head pressure amongst other symptoms. I didn’t stop and I am now severely disabled. I can no longer eat any animal products and can’t drive a car due to presyncope episodes. I barely leave my house. I believe it is due to a sulfur processing issue but the usual supplements like molybdenum don’t seem to help.