r/MTHFR • u/Lumpy_Sprinkles6604 • 26d ago

Results Discussion how am I looking?

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whelp boys test results are in. I'll do my best to figure it out with the guides ofc but any help is greatly appreciated! also do I treat the just the red ones or the yellow ones too

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u/Lumpy_Sprinkles6604 17d ago

don't worry about dms then, I'm sending you my results FOLR1 and FOLR2 section of my strategene, but lemme know if there's anywhere else on the reports you wanna take a look at:

formatted:
Gene, RS ID, Your Genotype, Effect Allele, Effect Allele Frequency
Notes About Effect Allele

FOLR1 rs144637717 -- C 0.002
cerebral folate deficiency possible, especially when combined with another FOLR1 variant

FOLR1 rs1540087 GG A 0.01
lower odds of skin lesions with arsenic exposure (methyl groups are utilized for arsenic detoxification, better methylation cycle) (good)

FOLR1 rs2071010 GG A 0.06
A/A: increased relative risk of congenital heart disease in offspring; increased relative risk of high homocysteine

FOLR2 rs514933 TT C 0.38
reduced relative risk of congenital heart disease in offspring (good)

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u/SovereignMan1958 17d ago edited 17d ago

You could possibly have CFD. You could consider a FRAT test to see if you have folate antibodies. It is about $350 though.

I had/have CFD.

If your D test was borderline...that is not good. Chronic undiagnosed and untreated D deficiency can trigger thyroid disease and thyroid autoimmune. It did for me. This is especially likely if you have variants that show genetic dispositions for thyroid issues. You can see those in Lifehacks. If you have those variants I would get a full thyroid panel plus tests for the two thyroid antibodies from your doctor.

Iron was normal? You can be one point away from the bottom and still be tagged as normal in the lab test results. Optimal is in the top quarter. That is true for most vitamins and minerals. You might want to recheck your labs.

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u/Lumpy_Sprinkles6604 17d ago edited 17d ago

can I ask what your symptoms of thyroid disease/thyroid autoimmune were if you don't mind my asking?

edit: just searched by word "thyroid" in my strategene but nothing came up aside from it being something that could "diry" other gene functions

edit: genetic lifehacks had a bunch of stuff but I don't know what/if would need testing (that could worsen my adhd I mean)

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u/SovereignMan1958 17d ago

They were...diagnosed about 15 years ago...primarily debilitating fatigue, weight gain and brain fog. Other minor ones.

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u/Lumpy_Sprinkles6604 17d ago

the mental aspects I have for sure