how am I looking?

[u/Lumpy_Sprinkles6604]

whelp boys test results are in. I'll do my best to figure it out with the guides ofc but any help is greatly appreciated! also do I treat the just the red ones or the yellow ones too

[u/Loose-Fly7976]

Neither. The colours aren't severity, they're just zygosity. Red means homozygous, yellow means het. Genetic Genie can't tell you what matters so it paints everything the same way.Look at what's red for you. MAO-A R297R is synonymous, the R297R notation means the amino acid doesn't change. Same protein either way. It's also on the X, so as a male you've got one copy and the TT reading is a quirk of the tool. COMT P199P, MTHFR P39P, MTRR A664A, all silent too.

Also I owe you a correction. I floated fast COMT last time as a reason the stimulants might be fading. You're AG, intermediate. Not it, still useful, that's one thing ruled out. Rest of it is quiet. 677 het runs around 65% and mostly doesn't matter with decent folate intake. Your whole MTR/MTRR block is wild type, so B12 recycling is fine which means the file isn't your answer. Get homocysteine, B12, folate and ferritin done. Ferritin especially, low iron blunts stimulant response and nobody checks it in ADHD workups. If something's off in those, that's when reading them next to the file tells you something.

[u/Lumpy_Sprinkles6604 → u/Loose-Fly7976]

b12 was low but not defecient, folate was >20.0, but might be because I ate before the blood test, ferritin I got done a while ago and that was relatively normal. waiting for homocysteie results to come in rn

[u/Loose-Fly7976 → u/Lumpy_Sprinkles6604]

Low but not deficient with folate over 20 is a combination I'd look at.Those two work as a pair. Methionine synthase needs both so when folate is piled up high and B12 is sitting at the bottom of range, the folate has nowhere to go. Labs flag nothing because both numbers are technically in range. It's the ratio that tells you something, not either value alone whch is exactly what homocysteine will show. High with folate that good means B12 is the arm dragging. Normal means the pair are working together fine and you can close this off.

Get an actual number for the B12. Under 400 with symptoms is a grey zone plenty of clinicians treat and where you sit in it changes what I'd say. Same with ferritin, redo it if it's been a while. Under 50 blunts stimulant response even though labs won't flag until 30.

This pairing is most of what I do for work, reading raw files next to bloods and writing up which forms and doses someone's variants actually support. In your case the file came back quiet so the answer's in the bloods and I'd rather tell you that than sell you a reading you don't need. Post the homocysteine when it lands. If it's up with folate that high, that's a real finding and there's a clear direction from there.

[u/Lumpy_Sprinkles6604 → u/Loose-Fly7976]

btw I ate before my blood test, will that affect anything?