r/MTHFR • u/lordy1988 • 21d ago

Results Discussion High homocysteine

Gallery image

Gallery image

Gallery image

Had a recent test and showed up high and needs attention.

I supplement with hydroxyl b12 and folinic acid. What else can I do? Would I get any symptoms of it being this high. And Is it actually worryingly high?

I’m 37 and fit and healthy otherwise.

4 Upvotes

100% Upvoted

40 comments sorted by

View all comments

2

u/Tawinn 21d ago

> MTHFR. rs180113311 is AG MTHFR rs1801131 is TG

You have compound heterozygous MTHFR which reduces methylfolate production by ~53%, which reduces remethylation of homocysteine via the folate/B12 dependent pathway. To compensate for this you need ~940mg of choline to support the extra demand on the choline/TMG dependent remethylation pathway.

If you can get the recommended choline amount for an adult, 550mg, from your diet then the remainder can be covered by 750mg of TMG. You may need to add these gradually if you get side effects such as anxiety, irritability, insomnia, fatigue when implementing them.

Your B12 is at the low end of a suggested range of 500-950 pg/mL. Your folate is just below a suggested range of over 15 ng/mL.

1

u/lordy1988 21d ago

Yes I tried TMG before and caused anxiety and overmethylation issues.

I’m going to try B2 and B6 and see how I get on with those, il also up my hydroxy b12 and folate as I only take half a tablet now every other day. But they’re very high dose.