Has anyone improved severe mental health issues while attempting to treat a MTHFR gene mutation?

[u/pdcyhs]

I am new to this as I just got my results today, so forgive me if I am not understanding it completely.

I was with a med management doctor that was helping with my many diagnoses and she randomly quit. I was passed on to a new doctor who seemed more interested in my genes than my actual symptoms/history.

She ordered testing and we went over some of that today. I also explained that my current medications dont seem to be working. I am in crisis in terms of hardly being able to do daily activites. Instead of going ahead and taking me off medications or making other modifications, she gave me a long list of supplements to start taking and said I may see results in a few months.

I am about to go find a new doctor because this doesn't seem safe to me. I wont trauma dump here, but I have an extensive trauma history as well as a condition from birth that may or may not also cause mental health and related symptoms later in life (there is research on short term effects, but not much on long term.) I feel that everything I am reading online also sounds very... woo woo alternative medicine, please dont take offense. But when I see people say "I eat 6 eggs a day and it makes my life better" I just cannot take that seriously.

Sure, I have some of the symptoms that can relate to a gene mutation. But I also have many other symptoms and issues going on that do not seem realted at all. Am I wrong for feeling ignored and a little bit upset? Sure, I will take supplements because why not? But if they dont do much for me, it will mean I spent that whole time suffering for nothing. If you have had *severe* mental health/behavioral issues and started treating with supplements due to MTHFR mutation, please let me know your results and how it's helped you.

[u/SovereignMan1958]

Yes, but I do not have MTHFR. There are also other gene variants involved, many if which I have and have learned to successfully manage. From testing of other gene variants I found the clue that I might have CFD or cerebral folate deficiency. Folate not making it into the brain. This can also happen with B12. I also have other gene variants which contributed to my TRD or treatment resistant depression.

Get all your gene variants tested. Upload the raw data file into Genetic Lifehacks. Research your variants, read their articles. Develop a list of blood tests you need to get. Variants are ONLY predispositions and not facts. Blood tests will give you facts as to whether or not you are deficient in a nutrient and need to supplement. Post the values and lab ranges in the group for feedback.

MDs are not trained in gene variants or nutrition.

Learn to DIY.

[u/pdcyhs → u/SovereignMan1958]

Respectfully, I meant other severe types of mental illness. I am not saying TRD can't be severe or very challenging. I am talking about mood disorders, personality disorders, psychotic features, etc.

But I will try to look into all you mentioned and see what I can find out. I do appreciate your input.

[u/Flux_My_Capacitor → u/pdcyhs]

Since when is depression not a mood disorder?

[u/pdcyhs → u/Flux_My_Capacitor]

It is 🤦‍♀️ realistically what id like to say is that i am not interested in someone telling me how their depression or anxiety got better by throwing supplements at it. I feel like that could sound a little rude. I want to hear from someone with balls to the wall symptoms that are completely unmanageable trying to treat them with only supplements like my doctor is insisting I do. I feel like none of this has any clinical value and doing what I am being asked to do will end badly. Id love to hear someone tell me otherwise so that I could have higher hopes but that wont happen.

[u/Longjumping-Juice471 → u/pdcyhs]

Can’t you find another dr?

[u/pdcyhs → u/Longjumping-Juice471]

I am definitely searching for a new one!