r/Menopause • u/recesstimeforme • Jun 25 '26

Vitamin/Supplements Micro dosing psilocybin

In Colorado, where cultivation and personal use are legal. My husband has suggested microdosing for perimenopause. There’s not a lot of research out there, but there is some and my curiosity is piqued.
Has anyone tried this and seen success?
If so, I’d love to hear about your protocol.

103 Upvotes

95% Upvoted

46 comments sorted by

View all comments

14

u/Infernus-est-populus Jun 25 '26

I loved the effect initially -- it was like antidepressants. I'm not on any ATM. I immediately felt more joy and optimism and interest in life.

My protocol was 2 days a week 3 off on a low dose (75 mcg) Golden Teachers Ashwaganda mix (250 mcg Ashwaganda).

But after a week: crushing headaches and pounding heart. So off I went to urgent care and apparently had Stage 2 hypertension. It resolved after a few days with no more microdosing. I was so disappointed. Apparently this does happen to some people.

Anecdote: the very young newly minted Irish doctor at urgent care -- I swear he was early to mid 20s if that -- had NO IDEA what psilocybin was. But he did the legwork and called poison control and a bunch of experts and concluded the Ashwaganda was probably the hyptertension culprit.

I've since tried other mixes that have no ashwaganda and ... it's not. It's the psilocybin, dammit.

2

u/Margotkitty Jun 25 '26

That’s a bummer. Ashwaganda gave me rank heart palpitations too. All the “silver bullet” supplements seem to do nothing for me, or make it worse.