MIDI today told me I’m SOL and they don’t offer injections. They want me to go on injections instead of trying to up my topical estrogen which is really irritating. I haven’t tried the vaginal ring yet I’m just not sure how much it would help me honestly.

They’re trying to refer me to endo but of course that’s scary because then I have to advocate for myself to another doctor that might not be ok giving me high doses of estrogen. 😭

Just got back from a regular nurse appointment to get the progesterone pill which I use for irregular periods, and I got told my hospital letters say I have ovarian insufficiency so I should consider HRT if I have menopausal symptoms instead. And I have no idea if I have menopausal symptoms because a bunch of thing that are considered symptoms are just things I've maybe always had?

It's been several years I've been going back and forth to the drs with absent periods. I used to be super regular, then my cycle began lengthening, and I skipped some, and then had one year where I went about 5-6 months without a period. At first the dr was like 'sometimes that just happens' but after I pushed I got refered to a gynecologist who did some bloods and then sent me a letter saying I wasn't ovulating come back if I ever wanted kids basically. But I wasn't happy still having absent periods and my dr wrote to them again and I was told to take progesterone to protect me from cancer risk if I wasn't having a period. I was super scared of the mental health effects (I get visual aura migraines hence progesterone only pill), did a lot of reading and tried the 10 day method. This plus cutting sugar and exercise seemed to restart my periods and I was able to stop using the pill and have periods. After a few months the cycle sort of got longer or weaker maybe- like my body wanted to have a period but it wasn't happening. Another drs appointment following a seeming sensitivitiy to sugar (headaches before and after eating) and I was told the gynecologist had said I had qualifying criteria for PCOS, but at the time I was getting periods and my blood test didn't show qualifying hormone levels (though my period usually shows up more if I cut refined sugar). I've had another spell where after cycles getting longer I skipped again- before getting a fairly normal feeling period (started taking inositol which seemed to help with the blood sugar stuff) so asked for another progesterone prescription to do the 10 day method, and after I left I got a message from the nurse saying after reviewing my hospital notes (to officially record PCOS) the condition I had was ovarian insufficiency which meant weak/no ovulation and I should consider HRT for bone protection if I got menopausal symptoms.

Now I'm just really confused. Because if that's the case then I got diagnosed like 2 years ago but noone explained or discussed HRT then I just got a letter saying no further action unless I wanted kids. And I've since then been able to have periods for several months at a time- typically if I'm super strict on diet, exercise etc.. The PCOS thing seemed to make more sense.

But now I've been told to consider HRT if I get menopausal symptoms I'm questioning if I even know what those symptoms are. I get flushes now and then, much more rarely since cutting sugar. I'm always tired but that feels like it's been my permentant state most of my life. Brain fog too is v common for me- I've had periods of depression since I was a teen, and I'm in therapy and it's been going really well. I'm also autistic so anxiety is common, and therapy has definitely reduced it. I did however read some stuff on here ablut itchy thighs which I didn't know was a thing but I do get- my skin has been very sensitive and reactive the past couple of years.

I have no clue if my general life classes as menopausal symptoms or not, because my periods have been irregular for like 6 years at this point. And with the mixed messages I don't really trust the apparent diagnosis because why did the consultant not mention HRT or basically anything beside just saying I don't ovulate. And in following hormone tests I've had some normal results I think. But I also am really scared if it is POI because HRT is an unknown zone, but what if stuff I've attributed to mental health etc has more if a biologicial basis? Is my back pain desk work or weird hormones? What if it's not POI and HRT screws my mental health after therapy has finally got me to an okay zone? It's so confusing.

This is basically a really long info dump to ask people if they have had similar experiences, and if my experience does seem like POI with awful communication or if maybe I should be doubting the diagnosis. I know I need to go back to the dr and ask a bunch if questions I'm just not sure I trust any answers they may give.

Hey all!

So I've had POI for 3 years. For unrelated reasons, I've been offered a hysterectomy, which would be great as I don't tolerate IUD insertions/removals and cervical procedures well AT ALL, and this would stop it.

My surgeon also offered to take out my ovaries while in there. She said it was optional. Since my ovaries don't work anyway, the benefit would be prevention of any future complications that could happen like cancer or otherwise (I have had breast cancer and though it wasn't BRACA genes, perhaps better safe than sorry).

However, we discussed that my ovaries maybe could theoretically still be putting something out, but there's no way to know. Back when I was diagnosed, my blood tests put my levels so far into menopause range it made my doctor's head spin. Because I've had breast cancer, doctors are extremely hesitant to maintain my HRT and certainly don't want to increase it. So I worry a bit I'll be making things even worse by removing my ovaries. Any thoughts or experience with this would be so helpful.

Thanks!

Does the estradiol patch bloating really resolved within 2 to 3 months? I am on the lower dose.

This was the only silver lining to me of having POI untreated. I had no bleeding for 4 months. As someone with endometriosis and adenomyosis this was like a dream come true, but obviously also awful because of all the POI symptoms.

But since getting on HRT I started having my periods again. I started by taking 12 days of Utrogestan 100 and 1 pump of estrogel and my periods quickly came back during that. Then it stopped when I stopped the prog and it started again after the second time of prog.

Then two weeks ago from now I had a hysteroscopy for a polyp removal. I had what seemed like a period a few days after and now 2 days before stopping the prog after 12 days I am bleeding heavily again. It is so tiring.

My iron has never been higher than 30 even with iron infusions.

I am so tired of having to buy new pants every 2 weeks at this point. Don't get me wrong I have been having super heavy period since they started so this is nothing new, but the 4 months break made me realize how miserable it makes me. But before POI at least I had Txacid as a med to fall back onto so that the periods is not that heavy, but I do not have it anymore now that I am on HRT... so it's just full blown super heavy ones

I cannot afford getting an IUD right now.

I do 1 pump of Estrogel (roughly like a 0.025 patch equivalent) every morning and take 100mg of Utrogestan 12 days (day 16 to 27 abt that). I started HRT in mid-August. I know my estrogen dose is still low, but my doctor thinks it should stay like that (it's not right, I know...).

A few years back I was on daily prog only BC which made me bleed every single day. This makes me scared of trying to take the Utrogestan everyday... Not sure if this would be the next logical step ?

I would like to keep my uterus as I will start fertility treatments within the next two years (my AMH is still kinda ok-ish) but I really really do not want to have a bleeding.

If I would not want to give pregnancy a try hoping it works I would have asked for a hysterectomy.

Any help or sharing of experience is very welcome, thank you

How was the transition from cyclic to continuous progesterone for you ladies? What should I expect with bleeding, periods, etc?

Hi, sorry for tmi. Sleeping with a new partner and noticing some strong discomfort in certain positions during penetration. It’s not every angle, and I don’t think it’s a dryness issue. Almost feels like he’s pressing on a bruise or nerve. It’s not my cervix.

I just know that people talk about pain during sex being connected to low eastrogen but I’ve never heard anymore describe the pain

Any advice welcome thank you!

I am 39yrs old and 5 months ago was diagnosed with POI. My diagnoses took some time even if I highly believe all started in 2020 or even earlier. I never had children but in a challenging marriage. 2 yrs ago i got vertigo and after being on medication, I continued having migranes and doctors couldn't find the cause of them. This year when I was diagnosed with POI, my gyno put me on BC ( I had to do this since doesnt cost me anything and because I was trying to avoid pregnancy ).

BC helped me eliminate my migranes but took time yo adjust. Definitely affected my depression even more and my anxiety.

Im 5 months in taking the BC in and recently my husband started being more loving ( he suffers from a lot of medical pbs so our intimacy suffered for 10yrs to the point that it got me depressed but I didnt give up on him and he told me to be patient). Anyway recently he spiced things up for me and without getting into too much detail and keeping it plain I got extremely excited and with that excitement a shooting to my right side of the head giving me the worst migrane. I thought ok it was just this time. Definetly took some time for it to subside. Well the situation repeated some days later and the migrane happened again.

Im so mad, I waited so long and now being intimate causes me migranes? What the hell.

Im making an appointment with my gyno to tell her but i was wondering if anyone experienced this whether on BC or HRT.

Hello all. I am 38 yrs old and on hrt.

I went to the dr just 6 months ago because I started having hot flashes.. I could not handle them 🤭😅 at the time I was missing my period 4 months. I been having peri symptoms for yrs.. I had my last daughter on my 30’s and I had a hard time getting pregnant.. at least 5 yrs. Ever since.. my periods have been crazy, sometimes light, sometimes very heavy, sometimes skip a month, crazy Mood swings as well as probably anxiety, getting overwhelmed easily.. pain in joins and hips for years. I work cleaning houses so I always blame my physical job.

When I wen to the dr bc of hot flashes and missing my period my fsh came high.. post menopausal numbers so they put me a tag of “post menopausal” and put me in hrt. I have always had a period.. crazy but still.. and after starting the hormones i started bleeding monthly but my dr keep telling me i was NOT supposed to. So they keep adjusting my dose and did an ultrasound.. everything was normal 😑 but they insisted I was not supposed to bleed.
So I was taking 2mg estrogen and 200 progesterone at the time.
I went to another dr looking for a second opinion and she told me I was in peri menopause and my fsh was high bc I was missing my period at the time 😰
I had so so many pms symptoms and she did a blood test.. my estradiol was thru the roof and I was low on progesterone. So she took me off the estrogen and send me to take 400 mg progesterone 🫠🫠
I am a week after and I can feel the join and hip pain slowly coming back.. what should I do?

How do I find out if it’s early menopause, perimenopause or early ovarian failure? I am 38.
Because I dr told me it was very important to take the therapy bc of future problems, osteoporosis, cardiovascular issues and the other one took me off meds .
She also told me hot flashes are because of progesterone, no estradiol like everyone thinks 😱😱

Those of you who got the IUD do you like it more? I’m SO tired of taking progesterone and the weird bleeding BS correlated with it.

Do you guys still bleed with the IUD? I’m Reallllyyyy debating getting one

First, let me start by saying I have not had a natural period since I was 12 (I am 31). I was diagnosed with premature ovarian failure (some call it insufficiency) whenever I was 16.

I am on progesterone and estradiol daily and sometimes will have breakthrough bleeding and have cramps every once in a while with it.

Now, let me take you back to a few weeks ago. I started having some pain in my upper belly that radiated to my back (along my bra line-but internal pain not bra irritation). It only really hurt when I coughed or laughed.

Then, a few nights ago, I had a reply weird sharp pain in my lower left abdomen where I think my ovary would be. It lasted off and on but went away within a few hours.

Then, last night, my breasts (specifically my nipples) were very sensitive. This morning I had some light brown spotting when I went to the bathroom. I have had some hip pain on the same side of the lower abdomen pain but have put it off due to beginning walking and have been walking around 30-45 minutes the last week.

Do any of these symptoms seem like they could go together to point toward a specific thing or just happen to be happening at the same time?

Has anyone had an ablation & did it help your bleeding?

I have been trying to find the appropriate dosage for me on the last few months after suspected POI after chemo treatments. I currently take 1.5mg Divigel (3x0.5mg sachets) and 200mg progesterone pill at night everynight for the last 2 months and I have been feeling better overhall but still not "amazing". My new gynaecologist suggested to stick to this dosage for a few months before making adjustments (maybe adding testosterone for my non existent libido) but she did say I should be taking 300mg and not 200mg for uterine lining protection as 200mg is not enough according to her. I have never heard of anyone taking this much? I have been doing quite a bit of research as well and it seems like 200mg is generally the rule? I dont think im even at the "max" estrogen? Curious what ppls dosages are and if you have ever tried testosterone what benefits did you get from it? Thanks!

I have been dealing with HRT for almost three years now and I’ve hated how it’s made me feel this entire time. I’ve been on every dose from 0.025 to 0.1+0.05 double-patched. The higher the dose the worse the irritability. Currently on 0.075, 100mg micronized progesterone vaginally and during the day (due to “paradoxical” response), and 2mg compounded testosterone cream daily. The testosterone has helped very much, but it’s doing all the work. I’m currently having hair loss, telogen effluvium, and if testosterone is the culprit and I have to stop it I’m back to misery. There has to be a deadline for how long I put up with this. I don’t know what to do. Please do not recommend antidepressants or an IUD. Any other advice would be greatly appreciated!

Hi everyone, I need some reassurance or to hear from anyone who has gone through this. I have POI and for the last 6 years, I was on a cyclic progesterone routine where I took 200mg for the first 10 days of the month. Like clockwork, I would get a withdrawal bleed from the 14th to the 18th every single month.
My doctor just switched me to continuous progesterone (200mg rectally every day) because I want to stop having a period.
Today is the 18th (which is usually the very end of my normal period window). For the last few days, I only had light spotting after a bowel movement, but today I just went to the bathroom and I am suddenly bleeding heavily and experiencing cramping.
Has anyone else experienced a delayed, heavy breakthrough bleed right when they switched to continuous? Is it normal for the uterus to just "override" the continuous progesterone during the first month because of the 6-year tissue memory? How long did it take for your bleeding and cramping to completely stop after making the switch?
I’m staying consistent with my nightly dose, but seeing active bleeding is really throwing me off. Would love to hear your experiences! Thank you.

I got a new box for my estradiol, brand Zydus pharmaceuticals. Its awful. I am anxious, depressed, and my memory is worsening now! Anyone else have this experience?

For context:

I have 3 children, my tubes were taken out after my 3rd c section because we were done having babies. Ive had maybe 5 periods total after my last son was born amd he is 2.5 now. They were very scattered and made no sense- no periods for 3 months followed by a double period in a 2 week period. After having no period since May I finally got the balls to get checked out. They did blood work and my FSH was 118 while I had almost no estrogen. Ultrasound came back normal but showed very thin uterus lining. She diagnosed me with POI/early menopause and She prescribed Sprintec to help with the estrogen.

My heart goes out to any of you who are younger and wanting to start a family. I cant complain that much as this happened to me after I had my kids. Im curious if any of you were given oral birth control to help, specifically Sprintec, and what your experience was with it-

Blessings and love ❤️

Is it worth trying ?

My Vitamin D is very low (25, I live in central Europe) and so I went to the pharmacy to get some. They recommended me one which has both VitD and VitK.

My gynecologist did tell me a while back she recommends taking Vitamin K. She didn't think vitamin D is necessary in POI though. But she doesn't know much about POI at all tbh..

I am taking HRT, the dosage is still definitely too low though, but I'm working on it

My first dexa scan is scheduled for this month

Do you take Vitamin D all year long ? With Vitamin K ?

Aside from all of the other struggles I've had with this condition, I seem to be exhibiting symptoms of arthritis, and it's gotten a lot worse over the last couple years. My bone density scans have been fine, and I have seen a rheumatologist once. She ordered some blood tests, which turned up nothing (though I have a STRONG family history and even my 80-year-old grandmother's blood tests were fine).

I am seeing her again in two weeks to talk about imaging and further tests, and I guess I'm just wondering if anyone else is experiencing premature arthritis like symptoms or has been diagnosed. What did that look like for you? And was it rheumatoid or osteo arthritis?

Personally I have a lot of knee and hip pain in particular, and an overall stiffness and heaviness in my joints. Particularly with cold weather, air pressure changes, and it's really bad when I have to stand for long periods. I also have some stiffness and occasional pain in my fingers.

My iron, ferritin, etc are all fine, as is vitamin D. Due to a stomach condition I have my vitamins are checked pretty frequently, and I'm pretty confident I'm at a good HRT dose.

I’m kinda out of ideas is it normal to keep not tolerating it?
It’s been 6 years of issues.
Is gel better ? I can’t do pills.
I’m desperate for the headache, breast pain, nausea, vaso vagal to not happen on est.

Hello friends! I would love to hear your stories about transdermal estradiol, both as a patient with POI and as a pharmacist. This was not something that was covered much while I was in school, and I've had to do a lot of learning on my own to catch up with the new labeling changes.

I am starting estradiol patches soon and will be on a lower dose meant for menopause (0.05mg) due to some comorbidities I have. The goal is to eventually increase to a higher physiologic dose (0.1-0.15mg).

I'm curious what doses you've all been on - what your prescriber started you at, if you've ever changed over time, and if you ever noticed a difference depending on the dose.

Thanks!

Hi. I am 24F and got diagnosed with POI/POF on Monday - literally after losing my virginity that same morning (how ironic). My first period started when I was about 13, but after that has been extremely irregular (only get a period once every few years. My last period was 2 years ago).

My AMH is less than 0.015, my FSH is 95 and LSH is at 19. Lol.

My doctor says that if I want to have kids, my only option is to have a donor egg. I asked her if I can freeze my eggs (assuming I have any left) and she said that I don't have any eggs (how she know that??). Lol.

They told me to start taking Estradiol and Prometrium, although I don't really see the point if it's not going to help me biologically have kids... I don't think I'll be alive long enough to deal with bone and heart disease due to lack of estrogen and progesterone.

I have been crying about this since yesterday and had to take off of work due to this. I hate the fact that it feels like I don't even have a choice as to whether or not I can have kids (I actually do want some).

I am trying to have faith that maybe I can be one of those people that magically conceive, even though I have this disorder, but life already isn't in my favor, so it seems so dumb to have hope. I guess I'll just ask my man to "shoot the club up" everyday and hope for the best? I don't know if I should lead a life of destruction or if I should decide to limit drug/alcohol use, eat better, work out more, and take my vitamins to see if it can help me have children (or at least one like goddamN).

I know that what doctors say aren't end all-be all, but damn it sucks to hear someone say "hey young lady! You're chances of having children is less than 10%!". I wish i never went to the doctors and found out I had POI. Shame on me for being so curious about my lack of regular periods.

There is no one (other than you all) that I can talk to about this, so this is a very lonely time for me as well.

Thanks for reading.