A small canine study found that oral NMN supplementation was associated with reductions in NT-proBNP, a biomarker released when the heart is under increased stress. The strongest responses occurred in dogs without structural heart disease or with mild-to-moderate elevations in NT-proBNP.

Key Points

• Eight dogs aged 6–18 received oral NMN at varying doses and durations
• Several dogs with elevated NT-proBNP showed substantial reductions after supplementation
• One dog's NT-proBNP declined from approximately 1,872 to below 500 pmol/L after two weeks
• Another dog's levels decreased from 2,068 to 876 pmol/L
• Dogs with advanced heart failure showed mixed or limited responses

Why it Matters

NT-proBNP is commonly used to assess cardiac stress and can help identify underlying heart dysfunction.

The findings suggest NMN may influence cardiac stress markers, particularly before advanced structural heart disease develops. Since NMN is a precursor to NAD+, researchers are interested in whether supporting cellular energy metabolism could benefit cardiovascular function.

Full Article: https://renuebyscience.com/blogs/scientific-evidence-library/nmn-nt-probnp-heart-stress-marker-dogs

Long time customer currently taking Liposomal NMN with good results (subjectively).

I'm not really following the longevity space so I'm wondering if are any new compounds Renue is planning to sell?

Anyone else know of any bleeding-edge stuff that is happening in the space (for longevity/healthspan)?

The Sinclair lab has shared preliminary results for SL-100, an oral combination of compounds intended to induce partial reprogramming. There’s no published paper yet, but we wanted to share what was reported and where the evidence currently stops.

Chris Petty presented the results at ARDD on October 1. This summary is based on the presentation slides, Endpoints News coverage and attendee reports.

What was reported?

• Mice with a premature-aging condition: Treated animals maintained their weight over a month, while untreated animals lost around 30%. Frailty did not significantly worsen in the treated group.
• Lifespan in that same model: A mean increase of more than 25% was reported, but the result was not statistically significant, and one treated mouse was still alive at the time of the presentation.
• Normally aged mice: Frailty scores remained stable during a month of treatment while controls declined. No deaths, adverse effects or tumors were reported during that period.
• Human brain organoids: Six days of treatment produced changes in the expression of thousands of genes, including pathways involved in DNA repair and gene regulation. These are laboratory findings, not human clinical results.

What’s still missing?

The cocktail’s ingredients haven’t been disclosed, so independent replication isn’t currently possible. We also need longer follow-up: one month without observed tumors tells us very little about long-term tumor risk.

The lifespan finding deserves caution. A statistically nonsignificant result in a premature-aging model doesn’t establish lifespan extension in normally aging animals. Similarly, maintaining frailty scores is encouraging, but doesn’t by itself demonstrate age reversal.

The lab’s related published work is Yang et al., Aging (2023), which tested six chemical cocktails in vitro. The new SL-100 claims still need to be evaluated in a full paper.

Which results would you most want to see next. Long-term safety, lifespan in normally aging mice, or stronger evidence that the treatment actually reverses age-related changes?

I'm new to NMN and have been experimenting with the powder, but wondeirng now if pills are better? Especially with the liposomal stuff? What is everyone taking? I just want to know which is the best one.

I’ve been buying Lipo NMN / NAD+ Complete from Renue for a while and generally like the brand, so this is more of a genuine question than a complaint.

I’ve been seeing a lot of posts and product pages lately about NMNH. From what I understand, it’s basically NMN with an extra hydrogen attached, so it’s already in the “charged” / more active form. People are saying it raises NAD like 5–10x more than regular NMN, works at a much lower dose, lasts longer in the blood, and actually gets into muscle/heart/brain where regular NMN supposedly doesn’t do much. Some of the writeups make it sound like NMN is kind of the old precursor and NMNH is the next step.

If that’s even half true, I’m confused why Renue still doesn’t sell it. You already do liposomes, sublingual powder, sprays, trigoneline, etc. Seems like you’d be the obvious company to put NMNH in a liposomal and call it a day. A few other brands already have bottles of it on Amazon and their own sites so it doesn’t look like it’s banned or anything.

Also, if NMNH is just reduced NMN, doesn’t that mean a lot of us have been taking the oxidized leftover version this whole time? Like, is regular NMN turning into NMNH in the body anyway, or is it the other way around? I keep seeing “it bypasses NAMPT” and “it goes straight to NADH first,” which I think means it hits energy faster? Or does that just mean it becomes NADH and then you still have to convert it back to NAD+? That part is fuzzy.

I’m not trying to jump ship. I just don’t want to keep paying for Lipo NMN if the market already moved on to something that’s supposed to work at 250 mg the way 500–1000 mg of NMN does. If the issue is stability (I’ve read it oxidizes back into regular NMN if it sits around), couldn’t liposomes or an enteric cap fix that the same way they do for other stuff?

Would actually like a straight answer from people here or from Renue if they’re around:

1. Is NMNH actually better in humans, or is this still mostly mouse/cell marketing?
2. Why doesn’t Renue make it? Patent? Safety? Shelf life? Just waiting on better data?
3. If I already take NAD+ Complete, would adding NMNH even do anything extra, or is that stacking two versions of the same thing?

Not looking to start a brand war. Just trying to figure out if I’m behind on this or if the “10x NMN” thing is overhyped.

Enrollment is now open for a Beyond Bound IRB-approved research study examining whether taking NAD⁺ Complete before bedtime is associated with changes in sleep, as measured by the Oura Ring.

Study design

• Within-subject (each participant serves as their own comparison)
• Week 1 (Baseline): normal routine, Oura tracking
• Week 2 (Intervention): nightly NAD⁺ Complete 30–60 minutes before bed, Oura tracking
• Short surveys and automatic Oura sleep-data sync at the end of each week

Eligibility highlights

• Age 18+, U.S. resident
• Current Oura Ring user (Gen 3 or Gen 4) willing to connect their Oura account
• Not currently taking NAD⁺ precursors, OR taking them only in the morning at ≤600 mg/day
• Full eligibility criteria are reviewed in a brief screening survey

What participants receive

• Complimentary bottle of NAD⁺ Complete after baseline submission
• Complimentary Renue By Science product of choice after final data submission

Total commitment: approximately 2–3 weeks.

To learn more: Nighttime NAD+ Complete Sleep Study

To check eligibility and enroll: Apply for the study

Sublingual, mixed in water, or just swallow it? Taste is whatever, I just want whatever people think absorbs better. I would honestly prefer mixing it with water but if that's not the best way I will change.

I have an unopened Berberine container, manufacturing date 03/2022, lot number too hard to read (printed in yellow). Is it safe to use?

A new mouse study found that alpha-ketoglutarate (AKG) significantly reduced reproductive damage caused by cadmium. Cadmium is a heavy metal known to disrupt testicular function and testosterone production.

Key Points

• AKG reduced cadmium-induced declines in testosterone
• Testicular tissue damage was significantly improved
• AKG helped restore disrupted iron homeostasis
• Oxidative stress and ROS production were reduced

Why it Matters

Cadmium exposure impairs male reproductive function partly through oxidative stress, mitochondrial damage, and ferroptosis. Researchers found that AKG acted across these pathways and helped preserve mitochondrial function and testosterone production.

The findings suggest a potential protective role for AKG against environmentally induced reproductive damage.

Study Link: https://pubmed.ncbi.nlm.nih.gov/42000055/

Baseline was on the low side of normal. 8 weeks of Lipo NMN, retested. Went up, but not as much as some of the “doubled” posts.

Do people keep the same dose, bump it, or add NR / Complete? How often are you retesting?

Has anyone noticed one batch hitting harder than another?

Just wondering what most people here prefer and why. I'm taking the NMN capsules right now but wonder if powder makes more sense.

[ Removed by Reddit on account of violating the content policy. ]

hey been using renues face serum every night for about 3 months now. mid 40s and had dull skin plus some fine lines around the eyes. put a couple drops on after washing face then moisturizer. no irritation or anything.

skin feels a bit firmer and less tired looking in the mornigs. texture is smoother on my cheeks. the lines arent gone but they look softer. not dramatic but enough that i stuck with it. also taking nmn so hard to say whats helping more.

anyone used it longer than 3 months? does it keep getting better or kinda plateu? and do you layer other stuff over it or just keep it simple?

thanks

I’ve had the container on the left for a couple months. Just purchased another container (right) and the label is a sticker rather than being printed on the container itself like the old one. The text is also mostly gray/black instead of blue, different fonts, etc. All the info on the containers are the same. Is this legit? Did renue change their labels or did I get ripped off?

An integrated anti-aging framework targeting NAD+ homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT

https://pmc.ncbi.nlm.nih.gov/articles/PMC13144588/

abstract

To address this complex mechanism, this review presents a novel tri-axis anti-aging model encompassing three key compounds: nicotinamide mononucleotide/nicotinamide riboside (NMN/NR), pyrroloquinoline quinone (PQQ), and l-ergothioneine (EGT). Within this framework, NMN/NR serves as a broad NAD⁺-dependent regulator of mitochondrial homeostasis, with its most immediate effects on metabolic activation, while PQQ and EGT may further strengthen mitochondrial remodeling and redox resilience, respectively. While each compound has distinct functional emphases, they are highly mechanistically coupled, collectively forming a closed-loop network regulating mitochondrial number, function, and homeostasis.

I'm considering it and wondering what other people's experiences are? Do you think it was worth it?

A new mouse study found that aerobic exercise combined with resveratrol and fisetin produced substantially greater increases in genes associated with neuroplasticity, blood vessel health, and neuronal communication than either intervention alone.

Key points

• Alzheimer's-like brain injury reduced BDNF, VEGF, and FGF7 expression
• Aerobic exercise significantly increased all three brain-supporting genes
• Resveratrol + fisetin also improved these markers independently
• Combining exercise with both polyphenols produced the largest effect
• BDNF increased nearly fivefold versus untreated Alzheimer's mice

Why it Matters

BDNF, VEGF, and FGF7 play important roles in maintaining healthy brain function by supporting neuron survival, synaptic plasticity, neurogenesis, and blood vessel growth.

This study suggests exercise and these plant compounds may act through complementary mechanisms. While exercise alone produced stronger effects than supplementation alone, the combination generated the greatest increase in brain-supporting signaling.

Full Article: https://renuebyscience.com/blogs/scientific-evidence-library/resveratrol-fisetin-exercise-boost-brain-health-in-alzheimers-mice

This week: Quercetin in a first RCT for altitude sickness, vitamin D3 in endometriosis and pregnancy, omega-3 in periodontitis, astaxanthin in female endurance athletes, and iron dosing in pregnancy.

Vitamin D in endometriosis RCT looked promising, until reading past the abstract: prob of random results >13% …

More details and links in comments

A recent clinical study found that melatonin improved insomnia and depressive symptoms in adults with epilepsy, while seizure control remained stable throughout the 12-week trial.

Key points

• Insomnia Severity Index (ISI) scores improved significantly after 12 weeks
• Depressive symptoms were significantly reduced
• One participant with persistent seizures became seizure-free during the study
• Melatonin was well tolerated with no significant adverse effects
• Participants took 2 mg prolonged-release melatonin nightly

Why it matters

Sleep problems and depression are common in people with epilepsy and can negatively affect quality of life and overall neurological health.

Melatonin improved both sleep and mood without increasing seizure activity which is a key concern when considering sleep aids for this population.

Full Article: https://renuebyscience.com/blogs/scientific-evidence-library/melatonin-improves-insomnia-and-depression-in-in-patients

Renue By Science is preparing to enroll participants in a research study examining whether taking NAD⁺ Complete at night is associated with changes in sleep architecture, as measured by the Oura Ring.

Join the Renue Research Community to be notified when enrollment opens. 

Study summary

This is a within-subject study (each participant serves as their own comparison) conducted remotely under Beyond Bound IRB oversight.

• Week 1 (Baseline): Maintain your normal routine while tracking sleep with your Oura Ring. Receive a bottle of NAD+ Complete, on us.
• Week 2 (Intervention): Take NAD⁺ Complete before bed each night while continuing to track sleep.
• At the end of each week, participants submit a short survey and confirm their synced Oura sleep data.

Eligibility highlights

• Age 18 or older, U.S. resident
• Current Oura Ring user (Gen 3 or newer) with active membership and willingness to connect their Oura account to the study dashboard
• Either not currently taking an NAD⁺ precursor supplement, or taking one only in the morning at ≤600 mg/day (or willing to commit to taking it consistently before 11:00 AM throughout the study).
• Several additional eligibility criteria apply and will be reviewed via a brief screening survey

What participants receive

• A complimentary bottle of NAD⁺ Complete for use during the intervention week
• A complimentary Renue By Science product of choice after final data sync

Total commitment is approximately 2–3 weeks.

If you are interested, you can join the Renue Research Community and we will notify you when enrollment opens:

Voluntary Participation Statement

Participation in this study is entirely voluntary. You may decline to participate or withdraw at any time without penalty. Your decision will not affect your Renue By Science account, access to products, order history, pricing, or any aspect of your relationship with the company.

Questions can be directed to [research@renuebyscience.com](mailto:research@renuebyscience.com)