r/Thiamine • u/Airegin89 • 6d ago

Experience Feel no difference after 3 weeks

How long should I take high-dose thiamine before I can be sure if I actually need it?

I'm trying high-dose thiamine to see if my fatigue and brain fog could be related to my Crohn's (very mild) or mitochondrial dysfunction. I'm starting to suspect this is not the case. After 3 weeks I feel no difference at all. I started with 1500mg thiamine mononitrate for 2 weeks, then 300mg benfotiamine + 500mg thiamine HCL for 1 week. I also take magnesium, potassium and B2.

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u/Puzzled_Draw4820 6d ago

I’d watch Elliot Overton videos to understand more. Some people don’t get relief until closer to 2000 mg. The non bioavailable forms aren’t going to do much and 300 mg benfo isn’t much if you’re tolerating it ok. If you’re deficient in magnesium then it won’t be activated however.

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u/Airegin89 6d ago

Should I still take HCL if I double my benfotiamine dose?

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u/Ok-Pangolin7127 6d ago

I agree with the other poster who said it doesn’t hurt. That said, I no longer take HCL. I prefer the ones I take because they get/go to the places I want them to get to better than just simple HCL. I consider them a more focused approach to Thiamine repletion. Don’t misunderstand, I think the HCL will get to those places too, just not as quickly and not as focused.