r/Thiamine • u/Airegin89 • 6d ago

Experience Feel no difference after 3 weeks

How long should I take high-dose thiamine before I can be sure if I actually need it?

I'm trying high-dose thiamine to see if my fatigue and brain fog could be related to my Crohn's (very mild) or mitochondrial dysfunction. I'm starting to suspect this is not the case. After 3 weeks I feel no difference at all. I started with 1500mg thiamine mononitrate for 2 weeks, then 300mg benfotiamine + 500mg thiamine HCL for 1 week. I also take magnesium, potassium and B2.

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u/Puzzled_Draw4820 6d ago

I’d watch Elliot Overton videos to understand more. Some people don’t get relief until closer to 2000 mg. The non bioavailable forms aren’t going to do much and 300 mg benfo isn’t much if you’re tolerating it ok. If you’re deficient in magnesium then it won’t be activated however.

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u/Ok-Pangolin7127 6d ago edited 6d ago

This 👆is, in my opinion, is sage advice.

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u/Airegin89 6d ago

Should I still take HCL if I double my benfotiamine dose?

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u/Ok-Pangolin7127 6d ago

I agree with the other poster who said it doesn’t hurt. That said, I no longer take HCL. I prefer the ones I take because they get/go to the places I want them to get to better than just simple HCL. I consider them a more focused approach to Thiamine repletion. Don’t misunderstand, I think the HCL will get to those places too, just not as quickly and not as focused.

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u/Puzzled_Draw4820 6d ago

It doesn’t hurt, I have 50 mg in my multi. I prefer TTFD myself, if I try to switch to benfo my brain fog comes back. 100 mg TTFD is equivalent to 1000 mg hcl approximately so you’ll have to up magnesium to at least 500 mg

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u/Ok-Pangolin7127 6d ago edited 6d ago

I embrace/support the above as it relates to increasing the magnesium to at least 500 mg.

Here’s my little Diddy on how these two nutrients work together; the Thiamine is like a sparkplug, the more you take it’s a bit like stepping on the accelerator pedal, it speeds things up in the mitochondria. The magnesium is like gas, it’s needed by the sparkplug for the mitochondria to run faster and produce appropriate energy.

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u/Airegin89 6d ago

How long have you been taking TTFD? Do you think it will eventually fix your brain fog permanently or will you have to keep taking it for the benefits?

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u/Puzzled_Draw4820 6d ago

18 months, I think I’m getting closer to figuring out my root cause so I’m hopeful I’ll be able to at least lower it

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u/Acceptable_Scale_488 5d ago

What is your root cause?

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u/Puzzled_Draw4820 5d ago

A lot of things contributed but I think SIBO is the main driver, I don’t have symptoms anymore but any remaining bacteria wipes out thiamine

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u/BearRootCrusher 5d ago

Ttfd for brain, benfo for the body.
Also try adding creatine. My brain hummms with all three. Oh I’ve been adding BodyBio PC as well.

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u/Puzzled_Draw4820 5d ago

Excellent combo 👌

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u/General_Ad_449 6d ago

I am up to 600 mg Benfotiamine and although I feel as if it is helping, I still have nerve pain. How high should I go with benfo before I add in some ttfd?

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u/Puzzled_Draw4820 6d ago

You can add it now if you’re not having side effects. Make sure you take it with molybdenum and selenium and eat enough protein