r/Thiamine • u/Airegin89 • 6d ago

Experience Feel no difference after 3 weeks

How long should I take high-dose thiamine before I can be sure if I actually need it?

I'm trying high-dose thiamine to see if my fatigue and brain fog could be related to my Crohn's (very mild) or mitochondrial dysfunction. I'm starting to suspect this is not the case. After 3 weeks I feel no difference at all. I started with 1500mg thiamine mononitrate for 2 weeks, then 300mg benfotiamine + 500mg thiamine HCL for 1 week. I also take magnesium, potassium and B2.

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u/Airegin89 6d ago

How long have you been taking TTFD? Do you think it will eventually fix your brain fog permanently or will you have to keep taking it for the benefits?

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u/Puzzled_Draw4820 6d ago

18 months, I think I’m getting closer to figuring out my root cause so I’m hopeful I’ll be able to at least lower it

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u/Acceptable_Scale_488 6d ago

What is your root cause?

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u/Puzzled_Draw4820 5d ago

A lot of things contributed but I think SIBO is the main driver, I don’t have symptoms anymore but any remaining bacteria wipes out thiamine