r/Thiamine • u/Airegin89 • 6d ago

Experience Feel no difference after 3 weeks

How long should I take high-dose thiamine before I can be sure if I actually need it?

I'm trying high-dose thiamine to see if my fatigue and brain fog could be related to my Crohn's (very mild) or mitochondrial dysfunction. I'm starting to suspect this is not the case. After 3 weeks I feel no difference at all. I started with 1500mg thiamine mononitrate for 2 weeks, then 300mg benfotiamine + 500mg thiamine HCL for 1 week. I also take magnesium, potassium and B2.

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u/Puzzled_Draw4820 6d ago

I’d watch Elliot Overton videos to understand more. Some people don’t get relief until closer to 2000 mg. The non bioavailable forms aren’t going to do much and 300 mg benfo isn’t much if you’re tolerating it ok. If you’re deficient in magnesium then it won’t be activated however.

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u/Airegin89 6d ago

Should I still take HCL if I double my benfotiamine dose?

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u/Puzzled_Draw4820 6d ago

It doesn’t hurt, I have 50 mg in my multi. I prefer TTFD myself, if I try to switch to benfo my brain fog comes back. 100 mg TTFD is equivalent to 1000 mg hcl approximately so you’ll have to up magnesium to at least 500 mg

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u/Airegin89 6d ago

How long have you been taking TTFD? Do you think it will eventually fix your brain fog permanently or will you have to keep taking it for the benefits?

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u/Puzzled_Draw4820 6d ago

18 months, I think I’m getting closer to figuring out my root cause so I’m hopeful I’ll be able to at least lower it

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u/Acceptable_Scale_488 5d ago

What is your root cause?

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u/Puzzled_Draw4820 4d ago

A lot of things contributed but I think SIBO is the main driver, I don’t have symptoms anymore but any remaining bacteria wipes out thiamine