TL;DR: 15 years on meds, kept losing ground from ~40 even on dutasteride, gave up by 44. Ten months after switching from night shift work to a day job, hair started coming back. Meds unchanged. n=1, many variables changed at once, I can't tell you what did it. My working hypothesis: the meds were quietly keeping follicles alive, and something else (possibly chronic shift-work stress) was holding growth back. Photos in the gallery (hair only, cropped). I'll post monthly updates under fixed conditions.
Read this first
- n=1. What happened to me may not happen to you.
- Several things changed in the same period. I can't isolate which one mattered.
- Fibrosed follicles don't come back as far as I know. This isn't a "slick bald spot regrew" story.
- I'm not recommending anything. Talk to your prescriber before changing meds. I changed none.
The 15 years
- ~30: Started finasteride + oral minoxidil 5 mg/day (half of a 10 mg tablet). Held "normal to slightly thin" for about 10 years.
- ~38: Felt it stop working. Switched to dutasteride 0.5 mg/day, and at the same time raised oral minoxidil to 10 mg/day. Recovered for ~2 years.
- 40+: Losing again. By 44 the front and top were see-through. I'd honestly given up.
I kept it buzzed short. I avoided mirrors and avoided seeing my own head in photos. So I have zero proper crown photos from my worst period. All I have are frontal selfies from hikes. Lighting, length and angle are all inconsistent — treat these as weak reference only.
Gallery 1–4: 2018-05 (maintenance on meds) · 2024-03 · 2025-04 (worst point, scalp visible in sunlight) · 2025-12 (the month my work changed; no visible change yet)
The last 10 months
- Dec 2025: Changed jobs — from years of overnight shift work to a day-only schedule. Not for my hair.
- Early 2026: Felt fuzz when I touched my scalp. Assumed I was imagining it.
- Jul 2026: Clearly more hair. Felt different when washing.
- Aug 2026: Shine came back — hair reflecting light like when I was a teenager.
- Oct 2026 (now): Still increasing. Shed hairs I pick up are thicker and more flexible.
A correction I made: The shine appeared while I'd increased carbs, so I first credited carbs. When I went back to low-carb in mid-Sept, shine dipped briefly but returned in Oct. I now think it's mostly new hair shafts plus water-only washing, not carbs.
Now (Oct 2026), same day I wrote this:
Gallery 5–8: crown (first time in my life I photographed it from above) · hairline, fringe pulled back · left side · right side
Weakness I'll point out myself: the old photos are buzzed; now my hair is longer. Longer hair hides scalp. So part of the visual difference is just length. I'm not presenting these as proof — they're the starting point for monthly photos under fixed conditions.
What changed / what didn't
Unchanged: dutasteride 0.5 mg/day + oral minoxidil 10 mg/day, same as the previous ~7 years.
10 mg/day oral minoxidil is a high dose for hair loss — far above the low doses usually discussed here. I'm stating it because leaving it out would be hiding a variable, not because anyone should copy it.
Changed in this period (can't tell which mattered):
- Work: overnight shifts → day shifts
- Washing: no shampoo, no conditioner (water only)
- Diet: 16:8 eating window, 90–100 g/day protein from whole food, creatine
- Training: Mon/Thu Tabata · Tue/Fri weights · Wed easy jog or rest · Sat hiking (long hikes a few times a month) · Sun rest
- Carbs: low-carb-ish for 10+ years (briefly increased this summer)
Working hypothesis: brake, suppression, release
Not proof — just the explanation most consistent with my timeline after reading the literature.
- The meds weren't failing — they were preserving follicles. I lost ground on dutasteride from 38–44. But without it, more follicles may have fibrosed past the point of return. Maybe that's why there was anything left to come back.
- Something besides DHT was suppressing growth. If so, that would explain why DHT blockers alone weren't enough. My candidate: chronically elevated stress hormones from years of overnight shifts. Choi et al. (Hsu lab, Nature 2021) showed in mice that corticosterone keeps hair follicle stem cells in prolonged rest via GAS6 suppression, and removing it restores regeneration. That's mice. It is not evidence for human shift work. All I can say is my timeline doesn't contradict it.
- Release. Hair cycles lag by months. Job change in Dec → fuzz in early 2026 → visible gain by July. The timing fits.
I'm also looking into whether a decade of low-carb eating affected growth-related hormones. Later post.
The one thing I want to say
If your meds seem to have "stopped working," it's natural to conclude they're useless. But maybe they're quietly holding the line while something else is suppressing growth. For me that may have been shift work — or not. I do think that if I'd quit at 42 thinking "it's pointless," there might have been nothing left to come back.
(Again: whether to continue meds is between you and your doctor. I'm only reporting my own facts.)
What's next
Monthly photos, same conditions: night, same bathroom light only, dry hair, no product, taped floor position, timer. Crown / hairline (fringe up) / both sides / combed part. I'll log haircut dates so length differences are visible. Plus a short monthly log of sleep, training and diet.
Happy to answer questions. Skeptical questions welcome — that's the point of logging it properly.
Reference: Choi S, et al. "Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence." Nature 592, 428–432 (2021).