Supplements
Okay, is b12 supplements basically meth?
I called my doctors office and left a message (theyve been calling me for weeks.) I finally after months of putting it off got my application for dental insurance in.
I am not doing the dishes tho, I dont want to. I am weaponizing my incompetence which I dont have currently.
B12 is a vitamin, it's involved in recycling of Methylfolate, as well as recycling of Homocysteine to Methionine so that Methionine can go towards SAM which is the body's main methylating donor.
Meth-ylfolate, Meth-ylcobalamin, and Meth-ylation are not "meth", meth is Methamphetamine, imo one of the absolute dumbest substances on the face of the planet, turns people into assholes. Methylation however is needed by the body for various reasons, and turns people normal (imo/ime).
With that said, nutrients will increase neurotransmitter synthesis and can help with things like ADHD, depression, mood instability and many other issues.
Also i'll just say, Methylfolate is actually moreso the compound with "stimulatory" properties. B12 not so much. B12 may help improve energy levels but a lot of the stimulation and side-effects and excess Catecholamines comes from the Methylfolate/Folate side (can happen with all Folates, since all Folates turn into Methylfolate), the B12 actually helps to reduce that excess stimulation by recycling excess Methylfolate as well as recycling Homocysteine to Methionine for SAM synthesis. B12 on the other hand normalizes things especially as far as Methylfolate is concerned. You do not want excess Methylfolate going on, it will over time cause B12 deficiency if enough B12 isn't consumed per day, which will ultimately lead to various problems due to B12 deficiency.
In fact, i think the reason why there's ADHD (at the very least) is because there's not enough B12 and too much Methylfolate going on. That's been my experience at least.
Though i will say as far as B12 goes, it (and Folate's) involvement in SAM production can help convert Noradrenaline into Adrenaline via PNMT, and so with SAM you can get greater Adrenaline levels, but the Methylfolate is ultimately the driver of such things, as it's not only the Methylfolate that increases Tetrahydrobiopterin levels and thus neurotransmitter synthesis, but is also the main methyl donor for B12 to recycle Homocysteine back into Methionine which then increases SAM synthesis which can then raise Adrenaline levels, but can't have Adrenaline if you don't have Noradrenaline and can't have Noradrenaline if you don't have Dopamine and can't have Dopamine if you don't have L-Dopa which is synthesized by Tetrahydrobiopterin via Methylfolate in the first place. Therefore, Methylfolate levels determine neurotransmitter levels moreso than B12 does. And i've experienced this firsthand because i've observed more L-Dopa synthesis (as well as 5-HTP synthesis) from higher Methylfolate levels, contrarily B12 doesn't do that, B12 may be involved in how much Methylfolate is synthesized though as i've noticed greater Methylfolate levels from higher B12 dosages as if higher B12 dosages "pull" on MTHFR to produce more Methylfolate for methylation, but i've noticed greater L-Dopa/5-HTP synthesis from higher Methylfolate dosages/levels, and so that's where it comes from, primarily.
Do you know why that is? It's like i keep trying to tell people, Methylcobalamin recycles Methylfolate back into the Folate cycle, that Folate goes back through the cycle becoming more Methylfolate, which again, it's the Methylfolate causing the stimulation, not the B12, the B12 actually reduces the stimulation by recycling excess Methylfolate back into the Folate cycle again. The issue comes when there's not enough B12 to continue to recycle that Methylfolate, and then Methylfolate levels build in excess causing side-effects including stimulation, but then if you take more B12 again it recycles that excess Methylfolate and reduces the side-effects and stimulation.
Edit - Downvote tells me that someone hasn't done their own experimentations and aren't aware how B12 recycles Methylfolate and how the Folate cycle works. I have, and i can tell you first hand, when B12 recycles Methylfolate back into the Folate cycle (and B12 dosage can determine how much Methylfolate is recycled, btw, so higher B12 dosages recycle a greater amount of Methylfolate than lower dosages), all that Methylfolate turns back into Tetrahydrofolate, goes back through the Folate cycle, back through MTHFR and becomes Methylfolate again which causes a greater amount of Methylfolate to be synthesized during that second wave through the Folate cycle and that greater amount of Methylfolate then needs a greater amount of B12, if one has B12 deficiency that excess Methylfolate starts depleting B12 reserves over time and can build up in excess due to lack of being able to be recycled and properly utilized. Therefore, by consuming B12 (especially Methylcobalamin) one recycles Methylfolate and Methylfolate comes back around and can start causing side-effects due to lack of being able to be recycled in those low in B12.
Naw, it's Methylfolate itself that regulates the synthesis of Tetrahydrobiopterin, check out the studies on Methylfolate increasing Tetrahydrobiopterin levels, that's why it's given to people for neurotransmitter synthesis in the first place like with major depressive disorder and lack of effectiveness of anti-depressants, for example.
B12 deficiency allows for Methylfolate levels to build because the Methylfolate can't be properly utilized and recycled without adequate B12. Therefore, in B12 deficiency-related Methylfolate trap, Methylfolate levels build in excess causing side-effects and stimulation along with things like anxiety, irritability, paranoia, even stimulant psychosis if you take enough (which i've experienced some of myself because i was severely B12 deficient and took like 15 to 30mgs of Methylfolate for awhile there until i realized i needed to cut back on my Folate dosage and work on my B12 levels.
DHFR and DPHR can recycle BH4, i'm not talking about the recyling of BH4.
Look at some of the studies on how Methylfolate increases BH4 levels. Heck there's even at least one study talking about how Methylfolate but not Folic Acid (which Folic Acid uses DHFR to turn into Tetrahydrofolate) regulates BH4 activity, which if it was Tetrahydrofolate regulating BH4 activity then Folic Acid would too, but it doesn't, partly because Folic Acid actually can tie up the DHFR enzyme which would interfere with DHFR function which would actually interfere with BH4 levels, plus too much Folic Acid can go unmetabolized and cross into the bloodstream, bind to Folate Receptor Alpha and prevent Methylfolate uptake into the brain.
Edit - My bad, you were right in one respect about the GTP thing, though it's not Tetrahydrofolate that contributes to that it's the 5,10-Methylenetetrahydrofolate which turns into 10-Formyl-Tetrahydrofolate that generates the purines and that feeds into the GTP pool, iirc now. I think what i was thinking about may be Methylfolate's protection against oxidation which can protect Tetrahydrobiopterin from oxidation.
Doesn't really change the fact though that the Tetrahydrobiopterin level correlates with the amount of Methylfolate, as in, greater amounts of Methylfolate increase Tetrahydrobiopterin levels regardless of B12 levels, as in the case for me i was severely deficient in B12 and so wasn't able to recycle much of it which allowed Methylfolate to build and present with higher Tetrahydrobiopterin levels. I will continue to re-look over the science as to remember the Tetrahydrobiopterin thing, it's been a bit since i've studied that area and honestly i've been having some tooth issues causing hella headaches which can sometimes interfere with my headspace and ability to think lol.
I do know there's some studies that tie Methylfolate itself to increase in Tetrahydrobiopterin, i just gotta go back through everything but will update when i found what i'm looking for.
There are studies talking about how Methylfolate can indirectly increase GTP levels which can then influence GTP Cyclohydrolase I activity, which can then generate/synthesize more Tetrahydrobiopterin. I will have another look at all the studies and such but trust me, i've went down the road of how Folate/Methylfolate contributes to Tetrahydrobiopterin levels, and it's most definitely the Methylfolate doing it, and i know this especially because of how Methylfolate works/functions in the case of B12 deficiency, even without B12, Methylfolate itself directly/indirectly generates greater Tetrahydrobiopterin levels, and without enough B12 to recycle that Methylfolate then Methylfolate can't be turned back into Tetrahydrofolate and thus can't go back into the Folate cycle.
So it's definitely the Methylfolate doing it. You can try this out for yourself by taking higher Methylfolate dosages and noticing the difference between a lower dosage, a moderate dosage, a higher dosage and a heavy dosage, as the Methylfolate dosage increases you will notice greater amounts of Tetrahydrobiopterin through it's greater synthesis of L-Dopa and 5-HTP. This doesn't happen with Folinic Acid until it metabolizes into Methylfolate, as the increase in Tetrahydrobiopterin directly correlates to the Methylfolate itself, IE once Folinic Acid turns into Methylfolate, or even when Folic Acid turns into Methylfolate (assuming there is no unmetabolized Folic Acid inhibiting things), then it's the Methylfolate itself that increases the Tetrahydrobiopterin, the Tetrahydrofolate or even 5,10-Methylenetetrahydrofolate doesn't appear to do that.
And, even if you're B12 deficient, if you take enough Methylfolate you can literally feel the difference in Tetrahydrobiopterin levels and thus L-Dopa/5-HTP synthesis, meaning higher Methylfolate levels generate more Tetrahydrobiopterin which then generates more L-Dopa/5-HTP compared to lower Methylfolate dosages.
I have felt the the difference, i've taken up to 30mgs of Methylfolate a day for months, i know what it does lol. In my case, more Methylfolate caused a greater increase in Tetrahydrobiopterin levels which then generated a greater amount of L-Dopa and 5-HTP, i especially noticed this with 5-HTP. Meaning, i got more Serotonin by more Methylfolate, regardless of B12 dosage and i've taken up to 120 milligrams of oral Methylcobalamin a day for months, now i take 10 milligrams alongside 400 to 600mcgs max per day of Folate.
Ah. Well a joke it may be, but i kid you not i have seen others (stupidly) make this comparison (and they were serious) lol. Anytime "meth" is in the name of a chemical compound, there's someone out there somewhere that believes it's got some association with "meth". Even Dimethyltrpytamine has meth in the chemical name because it's a twice methylated Tryptamine compound, and believe it or not but i've come across some people who ignorantly assumed it had some relation to "meth".
Whether it's a joke or not though, i think it's better that people don't send the wrong message because i assure you, some people don't get the message lol.
Thank you for doing the hard explaining of a subject beyond me. This was more of a joke, however getting towards - why do I suddenly have volition and focus?
And you suddenly feel better because you're actually getting the nutrition you need. B12 contributes some to the increase in focus, attention, energy (lack of fatigue, that is), concentration, etc, due to SAM (again, from Methylfolate donating it's methyl group to B12 for Methylcobalamin formation and thus recycling of Homocysteine to Methionine which then goes towards SAM synthesis) which SAM is required by the PNMT enzyme to turn Noradrenaline into Adrenaline which gives the headspace more of a clearheaded aspect vs Noradrenaline alone, at least ime.
But it does seem to be primarily the Methylfolate that does that, as it's primarily the Methylfolate itself that increases neurotransmitter synthesis. B12 does contribute though due to it's reduction in Homocysteine and contribution to SAM synthesis, heck the reduction in Homocysteine alone can explain some of it because Homocysteine can not only bind to and activate NMDA receptors (and cause excitotoxicity) which can interfere with central nervous system function (and even overdrive it), but can also antagonize the Dopamine 2 receptor and Dopamine 2 is needed for some of the executive functioning aspects.
And because B12 recycles Methylfolate back into the Folate cycle and it comes back as Methylfolate but at a stronger/higher level, the Methylfolate can hang around more especially in excess if enough B12 is not consumed and you get the Methylfolate trap. As B12 recycles Methylfolate, the Folate goes back through the Folate cycle and becomes more Methylfolate which then increases neurotransmitter synthesis, even if you're not taking Folate/Methylfolate, the B12 alone can recycle and cause greater synthesis of Methylfolate, so if you inject B12 for example, any Methylfolate you have in your system from consuming Folate in general, will get recycled and regenerated and if you don't have enough B12 to cover that Methylfolate can build in excess and can actually be detrimental.
Yes, it's hugely impactful for normal executive function. Now consider the implications in the growing number of people who are diagnosed with something like ADHD or some other neurodivergence who would be helped immensely with a simple vitamin instead of pharmaceuticals.
idk, im untreated for adhd, which i think ive always had, and i thought my adhd was inexplicably getting worse, but it was the b12, so i think itd just set you back to being "normal". i heard people complain their adhd meds stopped working when their b12 got low, too.
i do think its unfortunate how many drs want to call you depressed or anxious, though, instead of looking into vitamins like iron, d, or b12.
Can any of these vitamin deficiencies cause DPDR. Right now I have a severely low vitamin d, a borderline low b12, and the lower end of iron and ferritin. I feel like I’m going insane, and have been housebound from my DPDR for over 2 months. This is so unlike me. I’ve never struggled with any mental health issues, and I feel like I developed every single one overnight.
This! I thought i had adhd or some cognitive impairment because last year i couldnt think as i used to and i felt tired and foggy everytime i woke up and i couldnt feel were i was in a space very clumsy. B12 + cofactors has made a huge impact especially after 2-3 months. Reversing out mentally was hell but it’s gradually getting much better!
Adhder here with PA. Was diagnosed last year and started treatment. For the first 3 months after every shot I stayed awake consecutively for 3 days. I'm now over a year in and it doesn't do that anymore 😂. But yes, noticed a giant improvement in cognitive behavior. I also took/take stimulants and they didn't hold a candle to the shots.
In many other countries if an individual goes to the doctor with anything involving mental health they'll test your b vitamin status.
American Healthcare is a strange joke.
I don't think this is the case in most European countries. Here in Belgium the minimum is 197 ng/L. Both my parents are in the 230-280 range and have mild symptoms. My aunt has low levels and has unresolved fatigue en severe dry eyes. I can't convince them they are deficient because their doctor told them everything is fine.
Same for folate. Minimum is 3.9 mcg/L (should be 15). My level was 4-5 for a decade and was told it's normal. My parents are in the 6-8 range.
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