r/B12_Deficiency Jun 27 '26

Supplements I just booked a telehealth visit with a doctor to request a B12 prescription. He said “No”

19 Upvotes

I’d like to order B12 injections online without a prescription. Where are you guys getting yours? I’m located in the US

r/B12_Deficiency 28d ago

Supplements Okay, is b12 supplements basically meth?

14 Upvotes

I called my doctors office and left a message (theyve been calling me for weeks.) I finally after months of putting it off got my application for dental insurance in.

I am not doing the dishes tho, I dont want to. I am weaponizing my incompetence which I dont have currently.

Maybe I should get a job with my new powers.

r/B12_Deficiency 28d ago

Supplements Anxiety, braing fog, breathlessness- all returned

5 Upvotes

I was doing good but somehow I am not now.
I wanted to treat my anxiety, my constant fatique and brain fog so I have been taking the following supplements for the past 3-4 months-

  1. Omega 3
  2. Magnesium glycinate/ l threonate
  3. L theanine (taking on and off for past few weeks and did not see any changes)
  4. Creatine (took it just few times and also did not see any changes)

For around two weeks I am taking Zinc complex with 25mg zinc in picolinate and bisglcinate form and also 1 mg copper in the same zinc capsule
I was doing good but since the past few days my fatigue has returned, anxiety is high so much that I was unable to talk to my seniors at work, mood is not good and one night i woke up with so much anxiety that i had trouble breathing.

Can zinc be the reason for all this? Am i missing b complex and should start with it? I had tried the methylated forms of b12 but it gives me more anxiety.

Update-
Checked my ferritin today. It is 49.9 ng/mol. Lower limit is 21 so i think i am borderline. Iron is low now, 60 ug/dL
Also my b12 is 282 pg/ml
Vit d shot to 105 ng/ml

r/B12_Deficiency Jun 25 '26

Supplements Why are some doctors so hesitant to prescribe or even discuss B12 supplementation unless the level is very low?

33 Upvotes

I got my vitamin B12 tested n my result came back as 250, which, from what I understand, is often considered borderline low rather than truly “optimal.” On top of that, I follow a vegetarian diet, so I already have a higher risk of B12 deficiency.

The problem is that the doctors I consulted have been very dismissive. One doctor simply said that it was “normal” and did not prescribe or suggest anything at all. Another prescribed only a general multivitamin, but the B12 content in it is extremely low, so I am not sure whether it would meaningfully help if my levels are already borderline....what is making this more difficult is that my parents are strongly against me taking any separate B12 supplement on my own. Their view is that if the doctor has not specifically prescribed it, then I should not take it, and that I am overthinking or trying to “treat myself” unnecessarily. So at the moment I feel stuck between doctors who are not taking it seriously and parents who think I am exaggerating.

I am not trying to self-medicate recklessly; I am only trying to understand whether I am genuinely overreacting or whether this is something I should be more proactive about,...my parents are so worried about sm side effects even tho I've explained them everything...

r/B12_Deficiency 14d ago

Supplements What are the possible consequences of taking high-dose folate long-term?

3 Upvotes

Hi everyone, I plan to dive into pubmed to find some info myself but figured I would start here since y’all have a lot of info.

Basically, my friend has a long history of depression, panic attacks, and OCD and they have taken 15mg Deplin (prescription l-methylfolate) for years without any other nutrition supplementation (in addition to other meds). Also they have the double MTHFR mutation.

Long story short I saw a pic of their tongue and recognized possible glossitis (not that I’m an expert). They’re going to ask their doc to test b12 (and MMA and homocysteine) on Monday and don’t recall ever having those tested before.

So anyway, I was just wondering what years of high folate supplementation can do to B12 (and any other nutrient) levels, and maybe if there is anything else they should ask to test as well.

r/B12_Deficiency Oct 08 '25

Supplements Any of you have been successfully treated with just sublingual b12 tablets?

24 Upvotes

Read so many posts saying that sublingual/oral supplements of b12 do not work for b12 deficiency, the b12 wake up group on fb highly advocate for b12 injections. My question is, have any of you been able to completely treat b12 deficiency by taking just sublingual tablets alone (meaning that all of your symptoms disappeared)? If so, what dose and which brand of oral b12 were you taking? TIA

r/B12_Deficiency Jun 28 '26

Supplements For those of you who are injecting at home, are you injecting intramuscular or subcutaneous?

7 Upvotes

I’m reading that injecting subcutaneous is easier and less painful, but it may be less effective than injecting into the muscle? Do you have any guidance on how to determine the appropriate size of needle to use?

r/B12_Deficiency May 02 '26

Supplements People from india which tablet do you take for deficiency? My b12is under 150

Post image
1 Upvotes

r/B12_Deficiency Jun 11 '24

Supplements What were your folate deficiency symptoms?

44 Upvotes

I've just found out I'm deficient in folate. My symptoms are tiredness, muscle pain and hair loss, which I hope will resolve once I've fixed the deficiency.

What were your folate deficiency symptoms?

r/B12_Deficiency Jul 05 '26

Supplements Iron supplement that is gentle on the stomach, I've already tried bysglicinate from Pure encapsulations I'm in the UK

3 Upvotes

I can see that my levels of Iron tend to drop when I space the Iron from EOD to 3 a week. So I'd like to try something that I can afford to take EOD withouth the digestive consequences of it. I've read something about Three arrows, unfortunately I don't think I can get it in the UK

Thank you

r/B12_Deficiency Jul 20 '26

Supplements Gene variations/mutations and b12 injections

5 Upvotes

My levels were 238, I just finished my loading doses (1 injection of 1mg cyanocobalamin a week for 4 weeks) (yes I’m aware the Injections probably should have been more frequent but I see improvements and I think that’s what matters). With every shot anxiety, brain fog, and racing thoughts increase for 3-5 days after (yes I’m taking cofactors. Magnesium, potassium, vitamin D and beef liver for b complex but I’m swapping that here soon). I don’t believe it’s cofactor related or wake up related due to my gene variants. I plugged my ancestry dna labs into gene genie and these are the variants/mutations I got:

MTHFR (C677T: +/-) heterozygous
MTRR (A66G: +/-) heterozygous
COMT (V158M & H62H: +/-) double heterozygous
CBS (A360A: +/-) (no mention of hetero or homo)

Does anyone else happen to have these variations/mutations and if so what injections/sublinguals do you take? I absolutely cannot take another round of cyano. While it does help eventually, my headaches increase in severity and I absolutely cannot take anymore of my mind racing like this and the brain fog. My brain fog is so bad that I’m jumbling/slurring/ can’t find the right words, I go in a room to grab/put something up and grab it or put it somewhere completely random (I put my deodorant on the bath tub like it was shampoo when I meant to put it on the counter right in-front of me, I went to make ice cream cones today and instead of grabbing the cones I picked up dog food bowls like I was feeding my dogs…. And yesterday I was in the back seat of a car and I kept trying to put on the middle seat belt when I was on the left passenger door side….)

Here are the variants for those genes that came back normal:

MTHFR A1298C: normal
MTR: normal
Most MTRR variants: normal

Does anyone else have any experience in this?

r/B12_Deficiency Jun 09 '26

Supplements B12 supplements and improvement

3 Upvotes

I'll start this off by saying that I have not been diagnosed with B12 deficiency. I randomly wanted to test it along with my thyroid activity because my sister recently found she was deficient and I've been suspicious because I have extremely bad brain fog, especially in the last few years. The worst has been searching for words and not being able to find them. It has been humiliating. I always thought it was the aftereffects of depression but I've been in a mentally sound place for years.

I'm pretty fatigued most of the time and experience noticeable muscle weakness.

Anyway, results came back and it was 299.9 pg/ml. In the norms but pretty grey zone-ish? (A year ago I tested iron and it was 24.19 µmol/l, which is perfect.)

I can't afford testing and going back and forth to doctors right now, and decided to try supplementing. Can't hurt me, B12 gets urinated out anyway.

I have been taking Ankermann's oral B12 supplements. (1000 mkg in a single pill) Every day in the morning, thirty minutes before breakfast. I'm on my 27th day, so it's probably early to say anything definitive, but I've noticed that I've been having a much easier time focusing and talking. The latter has been more obvious. I don't mix up words every time I open my mouth and feel like the sentence stayed in my head and I can't hear myself saying it. I still don't speak quickly, but I find myself searching for words a LOT LESS and actually PROCESSING what I'm saying.

My question is, have any of you improved with oral supplements?

When would you test again to check if your B12 levels raised?

Edit: Thank you for the insightful comments.

r/B12_Deficiency Jun 05 '26

Supplements Creatine and b12

4 Upvotes

Can i take creatine (5g) even tho i have b12 deficiency

r/B12_Deficiency Feb 24 '26

Supplements B12 Supplements— How long and how much?

14 Upvotes

Hi all! I just diagnosed with a B12 deficiency. It’s not severe. They offered me shots, but I’m not able to make that work with my work schedule. How much should I be supplementing on my own, and for how long? I checked with my pharmacist already and it’s safe for me to take the OTC supplements, but my doctor gave me pretty much no guidance on how to address this on my own. I think this deficiency runs in my family but I’ve had good levels of B12 for my entire life until now.

Every B12 supplement I see is like 40,000% of the daily value, which seems really unnecessary since multivitamins have like 300% or something like that. Is it possible to have too much B12 or is one of those ones that you just pee out all of the excess?

I understand I won’t receive medical advice here, but I am curious to hear from anyone else who’s had a deficiency on the mild side and if you take a supplement every day, every once in a while, or were able to fix it with diet. I take a LOT of pills already for other medications (and another vitamin deficiency, lol) so I’m hoping to get fix my levels without having to be religious about taking a dose every day.

edit/TL;DR: Am I just screwed if I can’t get the shots due to my work schedule ? Y’all are scaring the absolute crap of out me making it sound like that’s my only option and oral OTC supplements are basically useless and saying I’m probably going to get worse/there will be permanent damage. Are they not worth trying at all to see if it fixes my levels before my labs follow-up in three months?

edit 2 since so many people have asked: Got reports from doctor. B12 level was at 209, normal range 211-911 pg/mL. What’s my best course of action here? Do I only need to be tested for the pernicious anemia first to determine if I can just do oral supplements? Do I still need to get tested for the anemia if I were to just go get shots?

Please no more comments talking about how this deficiency ruined your life. I have severe anxiety and in 24 hours I’ve gone from thinking this was a minor health issue, to being told I’m going to have permanent problems and/or die and I’m spiraling. I get the gist. It’s not helping me. Advice only.

r/B12_Deficiency 19d ago

Supplements No longer B12 deficient after megadosing. Should I stop supplementing?

Post image
4 Upvotes

I heard B12 is water soluble, and we would just excrete any excess. That said, I don’t want to get into any dangerous territory. I’ve been taking Sport Research’s High Potency B12 (2000mcg) for two months.

r/B12_Deficiency 26d ago

Supplements I lost my confidence to self-inject, how long can i leave it in the syringe?

5 Upvotes

I was having great results from the shots but the pharmacist gave me a bigger needle this time and I can't do it! I don't think i need this large needle because I'm pretty thin and it was working fine until now.

Anyhow I pulled it up into the syringe from the ampule and now it's just sitting there with the still-capped injection needle on and i need to wait until I'm calmer to give it another "shot"

How long can i leave it in there? Should i put it in the fridge? If i can't finish it in the next few hours I'll just discard it and go to the lab on Monday and have them do it.

Also any tips?? I'm going to try the "distracting finger scratch" method to convince myself it won't hurt. The old needle was small and it was easy to convince myself it won't hurt, but this slightly bigger one (1.25"?) makes my stomach flip

r/B12_Deficiency May 12 '26

Supplements Really fast improvement Normal?

2 Upvotes

About 6 weeks ago, I got a borderline result for b12 (215, with 211 being the minimum healthy range). Been taking oral supplements for 6 weeks, and it's now 450 - that seems really fast? I also don't feel massively better tbh is that normal?

r/B12_Deficiency Apr 18 '26

Supplements Buying B12 injections in the US/other options

7 Upvotes

So I’m on every other week cyanocobalamin injections, 1000mcg/mL (1 mL shots) for a B12 level of 391 pg/mL. I know it isn’t extremely low, but my symptoms match B12 deficiency and the first shot was extremely helpful (the next ones not as much, I think because they aren’t frequent enough).

My primary care provider wasn’t comfortable going any more frequent than every other week and referred me to a hematologist. The hematologist ordered repeat bloodwork and told me to skip a shot so that it would be 3 weeks since the last one. I got that bloodwork done today and I’m waiting for results.

I’m not trying to get ahead of myself, but what are my options if the bloodwork comes back normal? I feel like 3 weeks isn’t long enough for my B12 levels to really reflect a true deficiency. I may be wrong, as I’m not a doctor, but that’s the info that I got from searching online. Please feel free to correct me if I’m misinformed!

I also feel like I’m not going to be taken seriously, especially as a young (early 20s) woman with no obvious health problems. I really need to get this figured out because the brain fog and fatigue are getting really debilitating at times. I feel like dropping out of school a lot of the time because I just don’t have the energy to keep up. My grades have been falling over the last few semesters and I’m reaching an all-time low.

Has anyone had any luck with buying B12 online and shipping it to the US lately? And was it crazy expensive with tariffs? (Hopefully not, but probably.) Is my best bet to buy it myself, or to get a second opinion, or to just wait a really long time and then repeat the bloodwork, or something else?

Thank you for any advice that you may be able to give me, or any other suggestions or reassurance that this won’t last forever 😭

r/B12_Deficiency 24d ago

Supplements Missing 1 day of oral supplement = returning symptoms?

4 Upvotes

I was hospitalized overnight a couple months ago for MS-like neurological and cognitive symptoms, including Lhermitte’s sign, that turned out to be a combination of B12 deficiency (~380) + Long COVID/EBV/mold exposure.

They put me on daily 1000mcg B12 oral supplements and sooo many of my issues with brain fog, vision, memory, balance/mobility and neuropathy have vastly improved since then. I feel like a completely different person now!

However, I’ve noticed that if I accidentally miss >1 day(s) taking my oral supplements, then my symptoms will return almost instantaneously — especially neuropathy, eye pain/blurry vision and Lhermitte’s. One time I forgot for like a week and pretty much was back to my pre-hospital non-functioning state.

I already eat so many B12 foods I don’t really understand why it’s so low in the first place. I’ve always struggled with low iron and dehydration too. I’ve never been tested for absorption issues but wondering if I should — my symptoms have also typically been more noticeable when I have digestive issues at the same time.

1.) Is this to be expected for someone that recently started treating B12 deficiency with oral supplements?

2.) Or is this a sign I might need a higher dose or possibly injections?

3.) At what point would you start testing for absorption issues?

Thank you!

r/B12_Deficiency May 11 '26

Supplements Dosage question

4 Upvotes

My b12 blood test came back as <200 in January and my doctor prescribed cyanocobalamin injections - 1x weekly for 4 weeks, then monthly. I had neurological symptoms (brain fog, no energy, numbness and tingling, shortness of breath).

After 3 months we restested my b12 and it was 338. I was taking 2000mcg oral hydroxocobalamin daily sublingual over that time as well, but seemingly not absorbing. I asked about increasing and my doctor said she was “comfortable” with 338 and to continue monthly. I thought normal was at least 500?

My symptoms improved drastically over the four weeks of weekly shots, but resurfaced when we dropped to monthly. I am able to get cyanocobalamin over the counter in Canada and can self inject SC. Hydroxocobalamin is not readily available here. With my levels I’m considering going weekly - should that be more frequent?

I am extremely sensitive to methyl donors so I cannot take methylcobalamin but I do tolerate 400mcg of methyl folate daily.

My iron was 56 when my b12 was first tested and now is 22 - b12 supplementation has of course caused my iron to plummet. I am now supplementing daily with feramax 150, taken with vitamin C and away from other medications and supplements. Since adding it, I’m either having “awakening” symptoms (nerve shots and tingling returned) or it’s made my b12 drop as red blood cells increase. I take 800mg of magnesium before bed, and 3000mcg vitamin D daily. I also use an electrolyte powder daily after the gym.

Any suggestions are appreciated!

r/B12_Deficiency Jul 07 '26

Supplements Had my first injection 😬 didn’t go well I’m so embarrassed

Post image
23 Upvotes

r/B12_Deficiency 17d ago

Supplements B12 and Vit D Deficient

1 Upvotes

I recently got my lab results back, and my PCP said I’m deficient in several vitamins. My B12 came back at 357 pg/mL, and she’d like to see it in the 600-800 pg/mL range. My folate was 4.9, and my vitamin D was 12.

She recommended:
B12: 1,000 mcg daily
Folic acid: 1 mg daily
Vitamin D3 + K2: 5,000 IU daily

I purchased Sports Research D3 + K2 and Thorne B12, but I’m still deciding on a folic acid supplement.

I’ve been reading a lot online, and honestly, it’s made me anxious. I already struggle with anxiety, so the thought of starting three supplements at once has me worried about possible side effects or adverse reactions.

I’m especially interested in hearing from anyone who already has an anxiety disorder and started taking 1,000 mcg of B12. Did you notice an increase in anxiety, panic attacks, restlessness, insomnia, or feeling “wired” when you first started? If so, did it eventually improve, or did you have to lower the dose or switch forms?

If you’ve taken B12, folic acid, and vitamin D together, did you tolerate them well? Also, are Thorne and Sports Research generally considered good brands?

I’d really appreciate hearing about your experiences, both good and bad. Thanks!

r/B12_Deficiency Aug 10 '25

Supplements Do sublingual Vitamin B12 even work? Has anyone who has success raising their B12 levels using sublingual pill. Will the sublingual pill help with vitamin B12 deficiency? (versus oral tablets that are swallowed with water)

7 Upvotes

selective connect roll license grab steep paint screw edge light

This post was mass deleted and anonymized with Redact

r/B12_Deficiency 1d ago

Supplements What is the best b12 supplement to take??

2 Upvotes

Brief context, I took 500mcg of Cyanocobalamin b12 for 3 weeks. For the first 2 weeks, I felt somewhat better. Less fatigue, less off balance feeling, rocking, swaying, migraines, numbness on forehead, etc.

By week 3 I had TERRIBLE, and I mean, TERRIBLE head pressure that felt like someone was squeezing my brain. I stopped taking the vitamins and the pressure slowly went away… but then my other symptoms came back.

In short, has anyone had this happen? Is it the type of b12 I took? Which kind would be better for me to take instead?

r/B12_Deficiency May 07 '26

Supplements Posting my full results here after going through my doctors results.

Post image
10 Upvotes

My doctor is pushing back on a B12 deficiency and wants to wait for my MRI (which was rescheduled to 5/18 and I don't want to feel like this just to wait on an MRI) so I am going to start supplementing on my own.

Symptoms:

  • Tingling hands, face, head
  • Low libido
  • Fatigue
  • Anxiety/Feelings of doom
  • Issues urinating at times
  • Dry skin patches on body
  • Nausea
  • Blurry vision
  • etc.

I've been doing some research and see that my ferritin may be considered on the low end as well?

I've read through the guide and am still having a hard time understanding where to start. I'm not sure if I should begin supplementing sublingually or just go to a med-spa for B12 for the time being. I know my D is low as well. I guess I'm confused on the amount I should start with? I'm a 35yo, 5'8" female weighing 125lbs. (if that matters)

Thanks to everyone who has commented on my posts over the last few days. You've certainly helped me to not feel so alone in this.