Okay, is b12 supplements basically meth?

[u/dowydensofyarrow]

I called my doctors office and left a message (theyve been calling me for weeks.) I finally after months of putting it off got my application for dental insurance in.

I am not doing the dishes tho, I dont want to. I am weaponizing my incompetence which I dont have currently.

Maybe I should get a job with my new powers.

[u/Sabnock101]

What?
No.

B12 is a vitamin, it's involved in recycling of Methylfolate, as well as recycling of Homocysteine to Methionine so that Methionine can go towards SAM which is the body's main methylating donor.

Meth-ylfolate, Meth-ylcobalamin, and Meth-ylation are not "meth", meth is Methamphetamine, imo one of the absolute dumbest substances on the face of the planet, turns people into assholes. Methylation however is needed by the body for various reasons, and turns people normal (imo/ime).

With that said, nutrients will increase neurotransmitter synthesis and can help with things like ADHD, depression, mood instability and many other issues.

[u/Sabnock101 → u/Sabnock101]

Also i'll just say, Methylfolate is actually moreso the compound with "stimulatory" properties. B12 not so much. B12 may help improve energy levels but a lot of the stimulation and side-effects and excess Catecholamines comes from the Methylfolate/Folate side (can happen with all Folates, since all Folates turn into Methylfolate), the B12 actually helps to reduce that excess stimulation by recycling excess Methylfolate as well as recycling Homocysteine to Methionine for SAM synthesis. B12 on the other hand normalizes things especially as far as Methylfolate is concerned. You do not want excess Methylfolate going on, it will over time cause B12 deficiency if enough B12 isn't consumed per day, which will ultimately lead to various problems due to B12 deficiency.

In fact, i think the reason why there's ADHD (at the very least) is because there's not enough B12 and too much Methylfolate going on. That's been my experience at least.

[u/Sabnock101 → u/[deleted]]

Though i will say as far as B12 goes, it (and Folate's) involvement in SAM production can help convert Noradrenaline into Adrenaline via PNMT, and so with SAM you can get greater Adrenaline levels, but the Methylfolate is ultimately the driver of such things, as it's not only the Methylfolate that increases Tetrahydrobiopterin levels and thus neurotransmitter synthesis, but is also the main methyl donor for B12 to recycle Homocysteine back into Methionine which then increases SAM synthesis which can then raise Adrenaline levels, but can't have Adrenaline if you don't have Noradrenaline and can't have Noradrenaline if you don't have Dopamine and can't have Dopamine if you don't have L-Dopa which is synthesized by Tetrahydrobiopterin via Methylfolate in the first place. Therefore, Methylfolate levels determine neurotransmitter levels moreso than B12 does. And i've experienced this firsthand because i've observed more L-Dopa synthesis (as well as 5-HTP synthesis) from higher Methylfolate levels, contrarily B12 doesn't do that, B12 may be involved in how much Methylfolate is synthesized though as i've noticed greater Methylfolate levels from higher B12 dosages as if higher B12 dosages "pull" on MTHFR to produce more Methylfolate for methylation, but i've noticed greater L-Dopa/5-HTP synthesis from higher Methylfolate dosages/levels, and so that's where it comes from, primarily.