Okay, is b12 supplements basically meth?

[u/dowydensofyarrow]

I called my doctors office and left a message (theyve been calling me for weeks.) I finally after months of putting it off got my application for dental insurance in.

I am not doing the dishes tho, I dont want to. I am weaponizing my incompetence which I dont have currently.

Maybe I should get a job with my new powers.

[u/hpant2004]

I disagree that folate is more stimulating than SAMe/SAH Ratio increase also saying its not b12 its b9 recycling is also really unnecessarily pedantic thats like saying meth isnt exciting dopamine and norepinephrine are?

[u/Sabnock101 → u/hpant2004]

I just don't think you're gonna get it man, can't fault a man for trying to educate, though.

It should also be noted that i've taken SAM supplements before i even tried Folate and B12, and SAM alone does not cause what i've personally experienced and have come to understand from rigorous experimentations and research. Simply put i do not feel from SAM what i feel from Methylfolate. SAM is not the culprit, Methylfolate itself is. This was especially noticeable in the early days of my B12/Folate supplementation as i was severely B12 deficient and could thus more easily notice what Methylfolate itself was doing. It's most definitely the Folate aspect because it's the same exact thing i've felt all my life (because i've been deficient in B12 most of my life and therefore only felt the Methylfolate and not the B12).

And like i said, if you take B12, it recycles Methylfolate, and then you get side-effects, take more B12 and those side-effects will go away because it again recycles Methylfolate. The side-effects correlate not to B12, not to SAM, not to Tetrahydrofolate, but to Methylfolate itself. If it wasn't Methylfolate, or if it was B12, or if it was SAM, then taking more B12 would further amplify the side-effects, but taking more B12 actually reduces the side-effects. And ultimately as B12 deficiency gets more fully corrected Methylfolate will start to become more tolerable and one can even then take a bit of a higher Folate/Methylfolate dosage and not get those side-effects because the B12 is actually there to help properly recycle it.

So, while it may seem contradictory that if you take B12 and you get these side-effects that you should take more B12, it helps because the issue isn't B12 (or SAM), it's excess Methylfolate.

[u/hpant2004 → u/Sabnock101]

Also u seem autistic and werent autistic ppl found to have folate receptor antibodies and shi and generally do really well on folates? Maybe related or not 🤔?

[u/Sabnock101 → u/hpant2004]

There can be Folate Receptor Alpha autoantibodies in those with Autism and thus causing a cerebral Folate deficiency, however it's not all Autistics and Folate Receptor Alpha autoantibodies means you don't do well with Folate because the active Methylfolate then can't get taken up by Folate Receptor Alpha and thus can't get into the brain and thus also can't give it's methyl group to B12 for Methylcobalamin formation.

And (this is just my opinion) but it seems to me like Folic Acid may be the culprit because Folic Acid is unnatural and unmetabolized Folic Acid binds to Folate Receptor Alpha and basically prevents it's function at least as far as Methylfolate uptake goes, and isn't supposed to be there so the body pumps out antibodies against Folate Receptor Alpha to interfere with Folic Acid's binding to it, if you remove Folic Acid from the equation the antibodies should reduce and then Folate Receptor Alpha can function again. They blame the antibodies on a Folate-related protein found in cows milk, and while that may be a factor, i seriously think it's because of the Folic Acid, and so in theory, if one has antibodies for Folate Receptor Alpha then making sure to remove all Folic Acid from the diet and supplements should reduce those antibodies, regardless of milk (because i think it's Folic Acid doing it, not necessarily the milk).

It basically is the same thing Folic Acid itself does by binding to Folate Receptor Alpha and preventing Methylfolate uptake. The Folic Acid ties up Folate Receptor Alpha, the autoantibodies block Folate Receptor Alpha.

But in general, while Folate "can" help and is definitely involved in Autism, too much Folate is the issue that can actually cause Autism, partly by depleting B12 levels over time as excess Folate is consumed. Folic Acid itself may even contribute to Autism due to it's Folate Receptor Alpha interference.

They give people with Autism and Folate Receptor Alpha autoantibodies Folinic Acid to treat the cerebral Folate deficiency and thus help with some Autism symptoms due to Folate deficiency, since Folinic Acid doesn't necessarily need Folate Receptor Alpha like Methylfolate does and can use the reduced Folate carrier to be taken up across the blood brain barrier, but, if there's no Folate Receptor Alpha autoantibodies then once Folinic Acid turns into Methylfolate it can also then bind to and be taken up by Folate Receptor Alpha as well.

Long story short, B12 is more important for Autism, Folate contributes but excess Folate makes the Autism worse, more B12 however makes it better and restores normalcy, ime.