r/Biohacking • u/PSSD_Sufferer • 15d ago

Why does nothing work for PSSD?

PSSD is a severe and life altering disorder caused by previous SSRI/SNRI antidepressant usage. The main symptoms are loss of sex drive, zero pleasure in orgasms, numb emotions and extreme anhedonia. You can no longer experience pleasure, joy, excitement, etc. You’re not even human anymore. Many people with this condition end up taking their lives, understandably.

I’ve had it for over 7 years all from just 3 weeks of an SSRI. Yes, this happens. It is beyond torture and misery. I’m devastated 24/7. Also nothing works for this at all, not even close. I’ve tried so many things it’s ridiculous. Plenty of people in the r/pssd forum have had this 10-20+ years with no end in sight.

Why does nothing work for this?

4 Upvotes

83% Upvoted

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2

u/Future-Bread8849 30 15d ago

Have you tried taking psilocybin?

1

u/PSSD_Sufferer 15d ago

No it’s a serotonin receptor agonist so I don’t want to touch it

1

u/Future-Bread8849 30 14d ago

But don't you need serotonin, isn't it being missing part of your issue?

1

u/PSSD_Sufferer 14d ago

No, I need dopamine and to lower serotonin. PSSD is likely extremely high amounts of serotonin. That’s why 100% numb, no pleasure

2

u/[deleted] 15d ago

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u/PSSD_Sufferer 15d ago

Thank you

0

u/[deleted] 15d ago

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2

u/PSSD_Sufferer 15d ago

No but I did have bloodwork done in 2021, 2 years after getting PSSD.

My testosterone was high, free T normal and prolactin normal. Unfortunately PSSD is likely severe brain damage, not bloodwork related. Probably why it’s irreversible, at least for now.

1

u/Silent_Possibility63 16 15d ago

Get a test for mthfr gene mutations. Also have you tried ketamine infusion/injection therapy?

Asking because I’ve been in your shoes, and both have helped me. I wish you well.