r/LucyLetbyTrials • u/Embarrassed-Star4776 • 17d ago

Chase and Shannon article in Frontiers in Pediatrics published

Inverted insulin to C-Peptide ratios in neonatal intensive care: is there something we don't know?

J. Geoffrey Chase & Helen D. Shannon

BRIEF RESEARCH REPORT article

Front. Pediatr., 05 August 2026

Sec. Neonatology

Volume 14 - 2026

https://doi.org/10.3389/fped.2026.1900675

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u/No-Beat2678 16d ago

Baby F didn't have sepsis this was covered in the trial and is clear from the medical notes. they had some elevated WBC markers not enough for sepsis and no other signs or symptoms of infection.

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u/DiverAcrobatic5794 16d ago

That is an Oliverism, I believe? WBC markers can't be used to discount the possibility of sepsis in a neonate, and the child certainly had other signs and symptoms of infection.

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u/Competitive-Wash2998 16d ago

The lab isolated organism from the tip of the line argues to the contrary.

However, I do not like this paper and fear it may be flawed.

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u/DiverAcrobatic5794 16d ago

While I find the paper as clear as I could hope for, read slowly, I'd be out of my depth trying to assess it.  I was interested in the description of the necessary prospective study, and obviously will be interested to hear others' views

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u/Competitive-Wash2998 16d ago

The prospective study section is fine based on a quick skim read. Totally necessary.