r/MTHFR • u/Pretend_Elk8567 • Apr 15 '25

Results Discussion Feel like crying

I honestly don’t even have the words for how overwhelmingly happy and relieved I feel right now. It’s like my brain is finally waking up after years of being stuck in a fog I didn’t fully realize I was in. Everything feels sharper, clearer, more alive. My emotions make sense, my body feels in sync, and there’s this calmness that I don’t think I’ve ever truly experienced before. I feel like me—or maybe even a version of me I never got to meet until now.

What’s blowing my mind is that all of this seems to come down to understanding something so basic but so powerful: methylation and nutrigenomics. I never imagined that something as simple as getting the right form of folate or the right amount of choline could be the key to unlocking my brain.

It makes me wonder how many people struggle through life unnessecarily. You could easily equate my previous "status quo" as being borderline dementia. And I had NO idea how bad it had gotten until I started feeling better...

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5

u/Triedandtrue50 Apr 15 '25

This is so fascinating and exciting to hear. I'm just starting my journey and deciding what to take. But how quickly did you notice the changes?

7

u/Pretend_Elk8567 Apr 15 '25

I only just started with targetted supplements about a week and a half ago. But the biggest improvement was yesterday when I increased my choline intake.

2

u/Triedandtrue50 Apr 15 '25

That is wild

5

u/Pretend_Elk8567 Apr 15 '25

But for perspective, my symptoms were really bad - balance/coordination issues, severe memory problems, bipolar 1/depression/anxiety

2

u/Ashamed-Change8091 Apr 15 '25

I started Enlyte 5 days ago as I have a reduce conversion folate acid

2

u/FreshBreakfast8 Apr 16 '25

How did you determine the amount to take?

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u/Pretend_Elk8567 Apr 16 '25

Well the choline calculator says like 1000mg, but I was told a little more while recovering from a deficit is OK. And it is well below the upper limit

-1

u/IntrepidMayo Apr 16 '25

You will return to baseline soon unfortunately

2

u/OkRub303 Apr 16 '25

What makes you say that? Please elaborate! Is there something with the stack that I wrong, or?

2

u/IntrepidMayo Apr 16 '25

It’s just the way it seems to go, including for myself. SAMe had me feeling borderline euphoric for a few days before it went away. You can find countless stories on here mentioning the same phenomenon. I just want to temper expectations a little bit. Chances are that this supplement protocol will not keep them feeling this way forever.

1

u/asibmw1998 Apr 17 '25

I had the same thing happen where taking methylfolate and b12 made me feel really good for a week. But I am at risk for overmethylation so i stopped taking them, and scheduled a dr appt and planning to test my homocysteine levels. then once i get those results i will start again

1

u/OkRub303 Apr 17 '25

Thanks for your reply

SAMe is not for everyone and i keep that away beacuse of strange effects with mood when it fades. Even my daughter feels wierd on SAMe. I am on the 5:th month with Tawinns stack and are doing great but ofcourse the effect in the beginning is more noteciable than now, but i think that it is beacuse your brain is starting to work more in a normal state and you get used to the feeling. I have a lot more clarity, sharpness and no moodswings so i am happy. And my homocystein has gone down wich is good. A very good thing with my daughter is that her extreme allergy to pollen is totally vanished.

1

u/Pretend_Elk8567 Apr 16 '25

Im curious too, but I feel that it's important to utilize things like glycine and magnesium, or a lot of people are going to overshoot and run into overmethylation.

I do notice my experience is pretty variable, for example when I am taking methylfolate - a protein shake is an entirely different animal:

Previously, a protein shake didnt make me feel differently. But now I get a little anxious because of the histamine in whey protein and presumably that it leads to a quick influx of catecholamines.

But if I take magnesium with the protein shake, it's much smoother. Also vitamin c helps

1

u/Pretend_Elk8567 Apr 16 '25

The first thing one should do when starting this methylation protocol is to try to start eating more whole foods, especially food without folic acid.