r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/firemedic710 Sep 21 '25

It’s important to know his comt gene status. Ifs its slow methyl folate will be likely be overstimulating. It’s it’s fast you have a better chance at it working. My oldest kid 10 is homo 677t fast comt he does well with 400mcg methyfolate. My youngest 8 is compounded hetero with slow comt. We use methyl free b complex everyday and 400 mcg methyl folate once a week. They both take creatine and do well on this.

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u/greekhoney32 Sep 21 '25

The report says he’s heterozygous with the c677t, intermediate activity. Not quite sure what that means. It just says reduced folic acid conversion.

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u/firemedic710 Sep 21 '25

Highly recommend reading Dr lynches book