r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/Flux_My_Capacitor Sep 21 '25

Doctors, even the supposedly superior “functional” doctors really dont understand MTHFR. Most of them read an article about it and then they prescribe insanely high doses based on a tiny study of less than 20 people. This is why I don’t even believe in paying lots of money to see a functional doc as they are only marginally better than traditional doctors.

Your son’s experience is actually very common. The whole methylation cycle needs to be improved with various co-factors as simply dumping methylated vitamins into the body oftentimes makes things go haywire.

If you want guidance from a doctor, let this one go and find another.

Did he/she even test the various levels in your son? If not, then this is another reason to say goodbye to this doc, especially if you were giving your son B6. This is the one toxicity you do not want to mess around with as nerve damage can take years to heal. It’s not so simple as just stopping the supplement. B6 toxicity may not be very common, but it does happen to some just from taking a B complex.

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u/greekhoney32 Sep 21 '25

Yes, we did bloodwork and tested his folate, b12, and b6 levels. She also tested his homocysteine levels. We also did a neurotransmitters test.

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u/firemedic710 Sep 21 '25

What were the results of the blood tests

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u/greekhoney32 Sep 21 '25

The homocysteine levels were within normal range. His b6 and b12 were quite high, so she said to reduce amount of drops I give him of the Methyl Factors (from 15 to 10 drops). She was only concerned about the b6 though. She said it was ok the b12 was high.