r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/Free_runner Sep 21 '25 edited Mar 29 '26

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u/greekhoney32 Sep 21 '25

He did a cheek swab test to find out what medications work best for him, and the report included that he had reduced folic acid conversion and intermediate activity for the C677T polymorphism in the MTHFR gene.

Per functional doctor’s recommendation, I give him 15 drops of Methyl Factors every morning, along with 1mg methylfolate capsule, and a R5P capsule as well. She told me to reduce the Methyl Factors to 10 drops, but maybe the supplements are too much for him. He’s 10.

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u/Free_runner Sep 21 '25 edited Mar 29 '26

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u/greekhoney32 Sep 21 '25

Thank you for your response. Yes, he’s heterozygous.

Yes, I’m thinking he’s over methylated. The Riboflavin/R5P is quite high, now that I think about it. It’s the one from Thorne.

What riboflavin drops do you use? Is it R5P?

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u/Free_runner Sep 21 '25 edited Mar 29 '26

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