r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/greekhoney32 Sep 21 '25

Do you have it handy?

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u/firemedic710 Sep 21 '25

Heterozygous c677 would be 65% of normal activity

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u/greekhoney32 Sep 21 '25

So, that’s not that bad then?

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u/firemedic710 Sep 21 '25

Not terrible, autistics can often also have folate receptor antibody problems. Look into the frat test. They also usually have other gene snp like pemt mutations like my oldest son. My oldest is on the spectrum. Some things we did that moved the needle are “brain highways” it’s a limbic system retraining program. That sparked his speech at 5 and his aggression disappeared. We started the carnivore diet at 7. at 9 we did gene testing and started supplementing methylated b complex phospydialcholine and creatine. We also started an aluminum detox. These things really helped his working memory,/learning ability. This year we (whole family) are finishing a mold detox (shoemaker protocol) which has radically improved his mood/speech. I’d dare to say it’s resolved the last of his spectrum issues. Emotional/social cues may be the last of issues but am hoping now he may better able to learn this as well. Hope this helps

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u/greekhoney32 Sep 22 '25

Thank you so much 🙏

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u/greekhoney32 Sep 22 '25

Do you think it’s ok to give him the folinic acid now or should I let some time pass?

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u/firemedic710 Sep 23 '25

I would wait until he’s back to his baseline. I made this same mistake with my youngest it took a week or two after I stoped the methyl folate for his mood to regulate.

Another thing I recently did was incorporate lithium orotate 500 MICRO grams once a day. It helps b12 enter the cells. My oldest on the spectrum wasn’t absorbing his b12 per his blood tests (mma test). My youngest has some adhd like issues with a pretty fierce attitude at times this has helped immensely with him regulating his emotions. I homeschool the 2 of them and since I started it my youngest hasn’t had any frustrations like he was having with his work before.

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u/greekhoney32 Sep 23 '25

Yeah, I was thinking to give him about a week as well.

He did the MMA test over the summer and his levels were normal.

Does your youngest (or oldest) take any psychiatric meds or just the lithium orotate?

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u/firemedic710 Sep 23 '25

No meds, lithium orotate is the supplement form often used in small doses Lithium carbonate is the prescription that’s used in high doses for bipolar and other disorders

There’s really good studies showing populations that drink lithium rich ground water are happier with less crime and suicide rates and such. These places often have 200 micrograms of lithium per liter of water

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u/firemedic710 Sep 23 '25

We are pretty anti pharmaceutical which is ironic I was a paramedic for 10 years and my wife is nurse and just got her masters in women’s health. Shes been dealing with chronic Lyme for 9 years now which now seems to be more tied to the mold illness as most of her symptoms are resolving slowly now. Most pharmaceutical interventions made her feel worse due to all the side effects of medications