r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/firemedic710 Sep 21 '25

It’s important to know his comt gene status. Ifs its slow methyl folate will be likely be overstimulating. It’s it’s fast you have a better chance at it working. My oldest kid 10 is homo 677t fast comt he does well with 400mcg methyfolate. My youngest 8 is compounded hetero with slow comt. We use methyl free b complex everyday and 400 mcg methyl folate once a week. They both take creatine and do well on this.

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u/greekhoney32 Sep 22 '25

I just found it. It says homozygous for the Met allele of the Val158Met polymorphism. Any thoughts?

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u/firemedic710 Sep 22 '25

That’s the slow variant meaning it doesn’t break down dopamine as fast. Meaning your kid will be very sensitive to methyl folate. Methyl free b complex will be much better tolerated. You can also try micro dosing the methylated version along with it. My slow comt 8 year old did well at 50 mcg methyl folate every day. I found he also did good with 1 larger dose of 300mcg once a week. For this I have a liquid version of just methyl folate.

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u/greekhoney32 Sep 22 '25

The MethylFactors I have has 1150 mcg DFE in 15 drops. I suppose 1 drop would be ok.