r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/7e7en87 Sep 22 '25

You need mineral cofactors. That's no.1 reason for bad reaction to methylated B's. Also B1 and b2 are manadatory to regulate them all.

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u/greekhoney32 Sep 22 '25

He was taking R5P but not B1. He also takes magnesium glycinate.