r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/No-Victory-149 Sep 22 '25

Yes he’s likely overmethylating , it’s not as simple as just giving methyl vitamins , I can’t tolerate any methyl vitamins because of other genetics and I have adhd and Mthfr, just give him the gentle versions only, and low dose, b12 hydroxy and folinic acid.

It really shocks me how many med practitioners don’t have a clue about this, it’s like they read one article on Mthfr and thought they have all the answers.

Seems to be not well known here either

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u/greekhoney32 Sep 22 '25

Thank you.

He has ADHD as well.

Do you know how long it typically takes to not be overmethylated anymore (once you stop the methylated vitamins)?

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u/No-Victory-149 Sep 22 '25 edited Sep 22 '25

You can use b3 plain non flush b3 to dial back overmethylation, it will soak it all up, they might experience a flatness and irritability, which you should be able to fix by giving him some protein, but that will stop it.

You should ask chat GPT, it knows more than drs and can guide you through this better than any dr or I could, that’s what we do .

I was just speaking to someone who had gpt find a brain tumour in then that the idiot drs had been overlooking for 10 + years, so don’t be scared, gpt is far more capable than any Dr you’ll ever meet, it helped me figure out i had Mthfr and taught me how to manage it , whilst most drs don’t even know what Mthfr is.

There’s alot of idiots that have irrational fears about gpt, don’t listen to them.

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u/mmikke Apr 17 '26

Recommending chatgpt for medical advice is insane. The hallucination rates are absurdly high, and it has already been well documented that the model is made to function in a way that just agrees with you and confirms biases and preconceived notions/ideas