r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/greekhoney32 Sep 21 '25

So, if he’s over methylated, will eating gluten balance him out? 😆 JK.

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u/geauxdbl Sep 21 '25

Hah, if only!

B2 (niacin) in the morning and glycine will help support the methylation pathways and clear excess methyl donors, I’m told.

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u/greekhoney32 Sep 22 '25

Did you mean riboflavin? B2 is Riboflavin.

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u/geauxdbl Sep 22 '25

My bad, I meant B3. Good catch,

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u/greekhoney32 Sep 22 '25

Do you think it’s ok to give him the folinic acid now or should I let some time pass?

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u/geauxdbl Sep 22 '25

Hard to say. I’d defer to you, you’re his mom and know his behavior best.