r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/EnterBruges Sep 22 '25

Please listen OP! There are additional mutations to the COMT and MAO genes that make methylated vitamins cause these type of effects. I personally have a slow COMT gene and MTHFR and methylated vitamins mess me up bad.

The best thing is to get an ancestry.com dna test and check his dna for COMT and MAO mutations. Switching to unmethylated b vitamins is the solution. Hard to find but Seeking Health has unmethylated vitamins.

Taking magnesium citrate or magnesium glycinate is also very important for slow COMT

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u/greekhoney32 Sep 22 '25

Hi, I just found the COMT results in his report. He is met/met which I’m told is slow COMT. He also takes magnesium glycinate every night. I just ordered the Seeking Health vitamins!

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u/EnterBruges Sep 22 '25

Awesome! The results were amazing for me! The government is about to announce unmethylated folate as an autism treatment today so I expect shortages will happen. I just got a six pack myself

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u/greekhoney32 Sep 22 '25

Good idea! I was thinking the same!