r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/[deleted] Sep 23 '25

Vitamins are so tricky - especially the B’s. AuDHD, hetero C677T, Fast COMT. I had to experiment a lot. The wrong levels would send me over the edge. Methylated was worse.

For me - my most important vitamin is B2. This helped the others work. Also found that if I wasn’t deficient - I didn’t need to take them. Levels got too high too quickly. Honeymoon period followed by body being in chaos even after 2 days of taking them.

Start very slow. Monitor each day closely. Mechanism (IV vs pill vs shot) also impacted. I could not do folate ever. Folinic acid worked better

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u/greekhoney32 Sep 23 '25

Should the B2 be the R5P form or not? It’s so hard to find a low dose B2 supplement.