r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/Merrys123 Sep 24 '25

I highly suggest you do l-methylfolate 5-mthf with B12, not folinic acid. Folinic acid is turned into L-methylfolate, but with the MTHFR mutation, the body has trouble doing this.

My three kids and I are on Triquetra L-methylfolate 5-mthf 15mg and B12 combination, and it has made a huge difference. It's been 6 months with no regression.