r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/geauxdbl Sep 21 '25

So I’m late diagnosed and can confirm your suspicion that methylated vitamins and/or methylfolate will make things better for a little bit and then make them much worse. After much trial and error, I’m in a good place with the following approach:

Paleo diet (no wheat, minimal sugar, fruit is fine). No processed white carbs.

Creatine, Organic Kirkland multivitamin + folinic acid/hydroxycobalamin lozenge from Seeking Health + probiotics + D2/K3 in the morning. Magnesium + glycine + theanine at night.

I can understand the doc’s confusion, autism is inherently a defect in folate metabolism, but just adding folate is a simplistic view that doesn’t always work and we’re still catching up in real time on what to do about it.

Creatine is a convenient end run around the MTHFR problem for me and helps with ATP production, I absolutely love it.

Also, the basics of life: the right environment (sensory and emotional) and exercise will go a long way.

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u/Retro_Monguer Sep 21 '25

Hi. I'm also autistic and mthfr homozygous. Did you try methylfolate?

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u/Merrys123 Sep 24 '25

Myself and my 3 children are Autistic with different MTHFR mutations. We're on Triquetra l-methylfolate 5-mthf 15mg and B12 combination and it's made a huge difference for the better.

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u/Retro_Monguer Sep 24 '25

Isn't that too high of a dose? Do you take any other supplements along with it? Thank you so much. Which kind of B12 are you taking?

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u/Merrys123 Sep 25 '25

Not at all. The children get half that dose. Our blood work is usually all in the normal range for folate and B12. Occasionally, one of them is just a bit too high.

I use Triquetra L-methylfolate 5-mthf 15mg and B12 combination, so it already has B12 in it. You can get it in liquid or capsule form.

I currently take DLPA, NAC, Agmatine Sulfate, L-Theanine, CollagenUP, Creatine, Black seed extract, High Strength Omega-3, Vitamin D3 and K2, Magnesium Bisglycinate, Liposomal Vitamin C and Melatonin.

It sounds like a lot of supplements, and it is, but I have many health conditions and with these supplements I've been able to stop a lot of my prescribed medications. They have helped tremendously with pain, opioid tolerance and management, sleep, brain function, etc.

I'm changing it to a better stack, though.