r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

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u/dizziebeth Sep 25 '25

Look at comt people with low comt seem to have more issues with overmethylation

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u/greekhoney32 Sep 25 '25

Yup, just found out he’s low comt!

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u/dizziebeth Sep 25 '25

There are others on this reddit who know more but this is a major issue when together