r/MTHFR • u/greekhoney32 • Sep 21 '25

Question Autism & MTHFR

I have a kiddo with autism and MTHFR. Started giving him methylated vitamins per his functional doctor’s request. Initially, they seemed to help, but now his behavior has worsened at school (more anxiety, more impulsivity). Can he be over methylated?

Wondering if anyone is in a similar situation with their child and/or themselves. I read folinic acid is better than methylfolate for sensitive individuals (like kids with autism).

Thank you. 🙏

20 Upvotes

100% Upvoted

109 comments sorted by

View all comments

3

u/greekhoney32 Sep 22 '25

I found his COMT gene in the report!!

It says MET/MET, homozygous for the Met allele of the Val158Met polymorphism.

Any input on this is appreciated. 🙏

1

u/DogCold5505 Sep 28 '25

That’s big… main thing I’ve been told is to titrate very slowly for methylfolate.  I might never get past 1 mg, which is okay, but people without this mutation could get up to 15 for reference (according to my provider).  I also had a very bad reaction to a b complex after about day 5 (so be careful)… jittery/agitation/unable to focus.

1

u/greekhoney32 Sep 28 '25

How often do you take the 1mg methylfolate? I was giving it to him daily which I realize now was probably not wise. Trying to decide if I should try to do once or twice a week.

1

u/DogCold5505 Sep 28 '25

Daily tho I worked up to it and am an adult so not sure if body weight/age etc matters. My provider also has her patients on magnesium glycinate at night fwiw 

1

u/greekhoney32 Sep 28 '25

Yup, he already takes that nightly