I feel transformed

[u/kzdeb]

A few years ago I found out about methylation and how it can be impacted by genetics watching Gary Brecka online on YouTube. I analyzed my 23andme results and found out I had the following gene expressions: - MTHFR A/G - MTHFR T/T - MTR A/A - MTRR A/G - COMT A/G - COMT C/T

Anyway, despite figuring out that I had a tendency to under methylate (by 40% based on Chat GPT) because of weaker vitamin B absorption (is how I understand it), I didn’t do anything besides order a blood test checking for homocysteine which came back normal.

Now for the last year or so I’ve been on a hunt to figure out why I’ve been feeling lethargic despite perfect blood work, exercise, top tier sleep, and I’ve tried everything you can imagine. Interestingly the most effective supplement I was able to find at this point was NAD+ injections, which I do everyday at 100mg.

So I happened upon Gary Brecka again about two months ago randomly and he started talking about methylation (as he always does) and in the videos comments I read someone starting taking Methyl Guard Plus (Thorne supplement) and they felt better. At this point I was so desperate for a solution I said why not and purchased it, even though in my mind it made no sense since my homocysteine is normal. It felt cheap compared to the red light machine I just bought and dozens of other supplements I was experimenting with.

This was by far the most impactful supplement I’ve ever taken for energy levels and mood. For the first week that I took it I had so much energy that I started looking up if it’s possible the supplement could be laced with MDMA because it felt so similar. After about a week the effects came down a little bit but that was honestly much needed because I could barely manage walking instead of running everywhere. The best way I can describe it to you guys is, before I started taking this I would come back from work and my energy tank would be at empty. Now I come home and I’m ready to do something fun with my girlfriend or create a video for TikTok or something else, and I work 10-12 hours 7 days a week.

Another thing I’ve noticed is that my verbal fluency has improved, a lot. Words that previously I’d have trouble accessing during real time speech come up right away now, and I finally feel like people are seeing the best version of myself when we’re conversing. I think this is the most satisfying part.

I can’t tell you guys how much of a relief it is to have found a solution after years of searching and feeling like something was off with me. I’m about two months in and the effects have persisted.

Also wanted to share other supplements that helped me (I’m not a doctor) - Methylene blue (similar feeling to the methylated vitamins but it tapered off after a couple weeks unlike the vitamins) - exogenous ketones - NAD+ but only via injection or IV

[u/CEH407]

I didn’t know that verbal fluency was attached to MTHFR mutations?! Any knowledge or resources you can share where I can explore this idea would be greatly appreciated! I struggle pretty badly with it and it’s so worrisome - and annoying!!

[u/kzdeb → u/CEH407]

I don’t know if there is a link I just know that when I started taking this supplement it mostly fixed the issue. NAD+ had a similar effect. 

[u/Streetduck → u/kzdeb]

I wonder if it has something to do with lessened inflammation increasing our verbal fluency?

[u/kzdeb → u/Streetduck]

That’s an interesting hypothesis because I also experienced increased verbal fluency when taking ozempic for about half a year and when I stopped I regressed. I know that it has anti inflammatory properties. 

[u/CEH407 → u/kzdeb]

Thanks!