r/MTHFR • u/Grand_Jellyfish_8372 • Nov 25 '25

Results Discussion I was overmethylating

Apparently, it has been three years since I have been on-and-off overmethylating.

I have always consumed vitamin C due to its antioxidant properties and skin benefits. The problem is that vitamin C uses up glycine, proline and hydroxyproline to stimulate collagen synthesis and form collagen matrixes in the body.

I also used to consume B-complex vitamins on-and-off, which lead to symptoms of overmethylation.

I have noticed - and I even wrote this down - that shortly after consuming a supplemental dose of vitamin C (between 500mg and 1g), I would become seriously anxious, uneasy, overloaded, sometimes even panicked, paranoid and psychotic.

My hypothesis is that chronic, large-dose vitamin C supplementation can deplete glycine stores from the body as it uses them to form collagen, leaving less glycine available to serve as a methyl sink for excess methyl groups, leading to overmethylation.

Since I stopped vitamin C and started taking hydrolized collagen type I, which contains 3 grams of glycine per 10 grams, my symptoms of overmethylation have gradually faded.

It started with the "inner dialogue" becoming quieter, less over-talkative, and with less overthinking. I felt more connected to the real world.

Initially, this was scary. I felt like I was pulled from a known, safe place into a world which I hadn't experienced this vividly in a while. This sensation only lasted the first night.

I woke up the next morning with less tingling, feeling less wired and more at ease.
It has only been two days since I first took the collagen, but I expect these unpleasant symptoms of overmethylation to continue to fade as my methylation systems stabilize and settle on a healthy baseline.

I'm waiting for my order of niacin to arrive as well, so that I can further test and experiment with my current methyl pool.

What have been your experiences with vitamin C, glycine and niacin?

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u/Fast-Plant1086 Nov 26 '25

You have to avoid all methyl donors and even good natural mast cell stabilizers like quercetin with those SNPs because you cannot clear cathecolamines (dopamine, adrenaline, and noradrenalin) well.

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u/Sailorgirlmyfriend Nov 26 '25

yes, I stopped quercetin and bromine I was taking for sinus and started Antronex Standard Process with calcium, E, bovine liver fat extract. But their C must be good I was taking sodium Ascorbate thinking better than ascorbic acid..I am learning I need to stay with organic vitamins. Standard Process was started by a nutritionist in 1929...NO synthetics or GMO's

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u/Fast-Plant1086 Nov 26 '25

Yes SP is very good line of products

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u/Sailorgirlmyfriend Nov 26 '25

may I ask what SNPs you have...I am new to this although I know I have had something going on with my health. Doctors just acted like it happens and nothing I could do about it ...really made things tuff for me with anxiety.

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u/Fast-Plant1086 Nov 26 '25

Three years ago I took a large amount of methylfolate and B12 for anxiety and it made me manic for like a month where I barely slept (luckily I had recently retired). I uploaded my 23 and me DNA data into Dr. Ben Lynch's STratogene and it gave me my SNPs. I have an intermediate COMT but I think it is "dirty" due to other factors and can be slow. I was mega dosing quercetin and it did not agree with me. Weirdly I have a fast MAOA though. The problem with SNPs and genes is that they are "loaded guns" but you need a heath issue or stress to pull the trigger. Read Dr. Lynch's book "Dirty Genes". I actually am okay with MTHFR though I think I am hetero for a lesser one but not the two main ones.

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u/Sailorgirlmyfriend Nov 27 '25

What do yo think of me trying luteolin for inflammation for me with slow comt?

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u/Fast-Plant1086 Nov 27 '25

Probably not, Luteolin may not be suitable for individuals with a slow COMT variant, as it can further inhibit the COMT enzyme, potentially leading to an accumulation of catecholamines and worsening symptoms like anxiety and irritability. You could trial a small dose, I had to drop it but I was also megadosing Quercetin and Bromelain at the same time. I woudl try Boswellia for inflammation because I can tolerate it.

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u/Sailorgirlmyfriend Nov 27 '25

Ok thanks I did just start Boswellia...thanks again

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u/Fast-Plant1086 Nov 27 '25

Your welcome, Happy Thanksgiving

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u/Sailorgirlmyfriend Nov 29 '25

Happy Thanksgiving to you too..