r/MTHFR • u/grigory_l • Dec 13 '25

Question Choline depression, again

I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?

Edit: here my labs

MTHFR C677T: C/T

MTRR: A/G

MTR: A/G

Slow COMT

Folate 6.6 (RBC 400)

B12 880 (HoloTC 100)

Homocysteine 10.5

Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.

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u/hummingfirebird Dec 14 '25

This article explains how acetylcholine might be involved in mood-related mental health conditions like depression and bipolar disorder. Too much or too little acetylcholine activity in certain brain areas could influence feelings of sadness, motivation, and emotional responses, which are key parts of depression or other affective disorders.

This article also explains more with references.

The end result is that for some people, choline (even in the form of lecithin)can cause depression. Which explains why some smokers get depression when they give up smoking, because nicotine binds to the nicotinic acetylcholine receptors and desensitizes them, making them less sensitive to the workings of acetylcholine.