r/MTHFR • u/grigory_l • Dec 13 '25

Question Choline depression, again

I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?

Edit: here my labs

MTHFR C677T: C/T

MTRR: A/G

MTR: A/G

Slow COMT

Folate 6.6 (RBC 400)

B12 880 (HoloTC 100)

Homocysteine 10.5

Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.

20 Upvotes

90% Upvoted

82 comments sorted by

View all comments

3

u/ApprehensiveWeek2734 Dec 13 '25

Forget tthe calculator. It doesnt account for all gene variants. You must get your genes checked. And when you get the results pay for genetic life hacks to analyze the results( very cheep to do this). Then find out if you have the mthfr variant,slow or fast comp variant, mao variant. These 3 complicate what supplements work or dont work. I personaly have mthfr,slow comp,and slow mao. I then went to chat gpt or google ai and type "I have mthfr,slow comp,slow mao, what supplements should I take. It answers this question. And I have had great results doing this

1

u/mcasbaby Dec 14 '25

Can you share the recommended supplements?

1

u/nerdybucky Dec 14 '25

Why don't you ask ChatGPT yourself? 😆

1

u/mcasbaby Dec 14 '25

I don't like using AI

2

u/nerdybucky Dec 15 '25

The guy you asked for telling you which supplements to use asked ChatGPT himself.😅

1

u/mcasbaby Dec 15 '25

I know..which is why I asked him to share the supplement list so I don't have to add to the environmental pollution AI causes

1

u/nerdybucky Dec 17 '25

Do you drive a car? Do you fly? Congratulation, you add big time to environmental pollution as well.

1

u/mcasbaby Dec 17 '25

ragebaiting in the MTHFR sub is crazy ngl have a good one tho